ACTIVIN-BINDING PROTEIN FROM RAT OVARY IS FOLLISTATIN
ACTIVIN-BINDING PROTEIN FROM RAT OVARY IS FOLLISTATIN
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DOI：
10.1126/science.2106159
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发表时间：
1990-02-16
期刊：
影响因子：
56.9
通讯作者：
SUGINO, H
中科院分区：
文献类型：
--
作者：
NAKAMURA, T;TAKIO, K;SUGINO, H
激活素，转化生长因子β的成员。蛋白质家族，最初从性腺液中分离出来，刺激垂体促卵泡激素（FSH）的释放。激活素在正常细胞和肿瘤细胞中具有多种功能。各种细胞合成激活素，并具有针对该肽的特异性结合位点。然而，其作用的分子基础尚不清楚。从大鼠卵巢中纯化了激活素的结合蛋白，该蛋白与卵泡抑制素（一种FSH释放的特异性抑制剂）相同。结合蛋白很可能参与激活素的多种调节作用。
Activin, a member of the transforming growth factor .beta. protein family, was originally isolated from gonadal fluids and stimulates the release of pituitary follicle-stimulating hormone (FSH). Activin has numerous functions in both normal and neoplastic cells. Various cells synthesize activin and have a specific binding site for this peptide. However, the molecular basis for its actions is unknown. A binding protein for activin was purified from rat ovary and was identical to follistatin, a specific inhibitor of FSH release. It is likely that the binding protein participates in the diverse regulatory actions of activin.