Proton-coupled electron transfer in biology: results from synergistic studies in natural and model systems.
Proton-coupled electron transfer in biology: results from synergistic studies in natural and model systems.
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DOI：
10.1146/annurev.biochem.78.080207.092132
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发表时间：
2009
影响因子：
16.6
通讯作者：
Nocera DG
中科院分区：
文献类型：
--
作者：
Reece SY;Nocera DG
质子耦合电子转移 (PCET) 是生物学中能量转换的基础。 PCET可以随着质子和电子的单向或双向转移而发生，并且可以同步或异步进行。为了说明 PCET 在生物学中的作用，本综述提出了互补的生物学和模型系统，通过氢键 [天青蛋白与供体-受体 (D-A) 氢键网络相比]、C-H 键的激活 [与 Fe(III) 金属络合物相比，醇脱氢酶和大豆脂氧合酶 (SLO)] 以及生成和运输来探索 PCET 在电子转移 (ET) 中的作用。 氨基酸自由基的影响[与酪氨酸修饰的光活性 Re(I) 和 Ru(II) 复合物相比，光系统 II (PSII) 和核糖核苷酸还原酶 (RNR)]。在提供这些比较时，生物学中 PCET 的基本原理得到了具体的说明。
Proton-coupled electron transfer (PCET) underpins energy conversion in biology. PCET may occur with the unidirectional or bidirectional transfer of a proton and electron and may proceed synchronously or asynchronously. To illustrate the role of PCET in biology, this review presents complementary biological and model systems that explore PCET in electron transfer (ET) through hydrogen bonds [azurin as compared to donor-acceptor (D–A) hydrogen-bonded networks], the activation of C–H bonds [alcohol dehydrogenase and soybean lipoxygenase (SLO) as compared to Fe(III) metal complexes], and the generation and transport of amino acid radicals [photosystem II (PSII) and ribonucleotide reductase (RNR)as compared to tyrosine-modified photoactive Re(I) and Ru(II) complexes]. In providing these comparisons, the fundamental principles of PCET in biology are illustrated in a tangible way.