Luteal phospholipase A2 activity increases during functional and structural luteolysis in pregnant rats
Luteal phospholipase A2 activity increases during functional and structural luteolysis in pregnant rats
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DOI：
10.1016/s0014-5793(99)00389-0
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发表时间：
1999-07-09
期刊：
影响因子：
3.5
通讯作者：
Hashimoto, I
中科院分区：
文献类型：
--
作者：
Kurusu, S;Kaizo, K;Hashimoto, I
我们测定了妊娠和产后大鼠黄体溶解过程中黄体胞浆磷脂酶A（2）的活性。黄体中磷脂酶A（2）活性及其代谢产物前列腺素F-2 α在临产前显著升高，并在产后结构性黄体溶解期间进一步短暂升高。幼仔吸吮刺激的缺失延迟了黄体退化，这与磷脂酶A（2）活性波动的改变和前列腺素F-2 α水平的降低有关。外源性催乳素有逆转作用。药理学和免疫化学特征表明，妊娠黄体中存在多种磷脂酶A（2）亚型。这些结果表明，磷脂酶A（2）活性增加，其可能的含义在黄体溶解在怀孕的大鼠。(C)1999年欧洲生物化学学会联合会。
We determined cytosolic phospholipase A(2) activity of the corpus luteum during luteolysis in pregnant and post-partum rats. Phospholipase A(2) activity and its metabolite prostaglandin F-2 alpha in the corpus luteum remarkably increased just before parturition and further rose transiently during post-partum structural luteolysis, The absence of a pups' suckling stimulus delayed corpus luteum involution, being associated with an altered fluctuation in phospholipase A(2) activity and depressed prostaglandin F-2 alpha levels. Exogenous prolactin had a reversal effect. Pharmacological and immunochemical characterization suggests multiple isoforms of phospholipase A(2) in a pregnant corpus luteum. These results show the increased phospholipase A(2) activity and its possible implication in luteolysis in pregnant rats. (C) 1999 Federation of European Biochemical Societies.