The consequences of uncontrollable stress are sensitive to duration of prior wheel running
The consequences of uncontrollable stress are sensitive to duration of prior wheel running
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DOI：
10.1016/j.brainres.2004.11.037
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发表时间：
2005-02-08
期刊：
影响因子：
2.9
通讯作者：
Fleshner, M
中科院分区：
文献类型：
--
作者：
Greenwood, BN;Foley, TE;Fleshner, M
不可控制的压力或习得性无助（LH）行为的行为后果被认为涉及中缝背核（DRN）中的多巴胺能（5-HT）神经元的过度活跃。其他与LH有关并能够影响5-HT系统的脑区，如终纹床核（BNST）、杏仁核和缰核，可能在不可控制的应激期间导致DRN 5-HT过度活跃。6周的车轮运行防止LH和衰减无法控制的压力诱导的c-Fos表达在DRN 5-HT神经元，虽然这些影响所需的车轮运行的持续时间是未知的。在目前的研究中，6周而不是3周的轮跑阻止了久坐大鼠无法控制的尾部电击产生的穿梭箱逃避缺陷和夸大的恐惧。与轮跑对LH行为的持续时间依赖性效应相对应，需要6周的轮跑来减弱不可控制的应激诱导的5-HT神经活性，该活性由DRN中的c-Fos蛋白表达和BNST的侧腹区域中的c-Fos表达来指示。车轮运行，无论持续时间，并没有影响c-Fos的表达在杏仁核或缰核的任何地方。这些数据表明，无法控制的压力的行为影响是敏感的持续时间之前的体力活动，并与假设的DRN 5-HT活性的衰减有助于防止LH轮运行是一致的。BNST在防止LH车轮运行的潜在作用进行了讨论。(C)2004 Elsevier B. V.保留所有权利。
The behavioral consequences of uncontrollable stress, or learned helplessness (LH) behaviors, are thought to involve hyperactivity of serotonergic (5-HT) neurons in the dorsal raphe nucleus (DRN). Other brain regions implicated in LH and capable of affecting 5-HT systems, such as the bed nucleus of the stria terminalis (BNST), amygdala, and habenula, could contribute to DRN 5-HT hyperactivity during uncontrollable stress. Six weeks of wheel running prevents LH and attenuates uncontrollable stress-induced c-Fos expression in DRN 5-HT neurons, although the duration of wheel running necessary for these effects is unknown. In the current study, 6 but not 3, weeks of wheel running blocked the shuttle box escape deficit and exaggerated fear produced by uncontrollable tail shock in sedentary rats. Corresponding to the duration-dependent effects of wheel running on LH behaviors, 6 weeks of wheel running was required to attenuate uncontrollable stress-induced 5-HT neural activity, indexed by c-Fos protein expression, in the DRN and c-Fos expression in the lateral ventral region of the BNST. Wheel running, regardless of duration, did not affect c-Fos expression anywhere in the amygdala or habenula. These data indicate that the behavioral effects of uncontrollable stress are sensitive to the duration of prior physical activity and are consistent with the hypothesis that attenuation of DRN 5-HT activity contributes to the prevention of LH by wheel running. The potential role of the BNST in the prevention of LH by wheel running is discussed. (C) 2004 Elsevier B.V. All rights reserved.