CELL AGGREGATION - ROLE OF ACID MUCOPOLYSACCHARIDES
CELL AGGREGATION - ROLE OF ACID MUCOPOLYSACCHARIDES
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DOI：
10.1126/science.175.4024.898
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
DEFENDI, V
中科院分区：
文献类型：
--
作者：
PESSAC, B;DEFENDI, V
几种类型的鸡胚和哺乳动物细胞培养物会释放诱导细胞聚集的因子。这些聚集因子也存在于一些血清中。每种测试制剂中的因子均通过牛睾丸透明质酸酶处理而灭活。相反，透明质酸仅促进那些通过含有因子的培养基聚集的细胞的聚集。这些因子似乎是酸性粘多糖，其中透明质酸是主要成分。
Factors that induce cell aggregation are released by several types of chick embryo and mammalian cell cultures. These aggregation factors are also present in some serums. The factors in each of the preparations tested were inactivated by treatment with bovine testicular hyaluronidase. Conversely, hyaluronic acid promoted aggregation of only those cells that were aggregated by media containing the factors. These factors appear to be acid mucopolysaccharides, with hyaluronic acid being a major component.