Mining the quantitative trait loci associated with oral glucose tolerance in the OLETF rat.
Mining the quantitative trait loci associated with oral glucose tolerance in the OLETF rat.
复制标题
挖掘 OLETF 大鼠中与口服葡萄糖耐量相关的数量性状位点。
DOI：
10.1142/9789814447331_0035
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发表时间：
1999
影响因子：
--
通讯作者：
S. Morishita
中科院分区：
文献类型：
--
作者：
A. Nakaya;H. Hishigaki;S. Morishita
虽然多个标记基因座的协同效应的数量性状，如血糖水平已经引起了人们的兴趣，以前的结论已经基于假设，每个标记基因座的行为独立于其他，导致近似。为了科普这一问题，本文着重于多个遗传因素的影响，并试图找到显着的标记组合，通过使用合取规则的基因型在多个标记位点。应用所提出的方法对OLETF模型大鼠的非胰岛素依赖型糖尿病（NIDDM），发现显着的组合标记位点的口服葡萄糖耐量（OGT）。
Although the synergetic effects of multiple marker loci regarding quantitative traits such as blood glucose level have attracted interest, previous conclusions have been based on assumptions that each marker locus behaves independently of the other, leading to approximation. To cope with this problem, this paper focuses on the effects of multiple genetic factors and tries to find significant marker combinations by using conjunctive rules regarding genotypes at multiple marker loci. Application of the proposed method on the OLETF model rat of non-insulin dependent diabetes mellitus (NIDDM) has found significant combinations of marker loci with respect to oral glucose tolerance (OGT).