GENETIC INFLUENCE ON SMOKING - A STUDY OF MALE TWINS
GENETIC INFLUENCE ON SMOKING - A STUDY OF MALE TWINS
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DOI：
10.1056/nejm199209173271201
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发表时间：
1992-09-17
影响因子：
158.5
通讯作者：
FABSITZ, R
中科院分区：
文献类型：
--
作者：
CARMELLI, D;SWAN, GE;FABSITZ, R
背景双胞胎和家庭研究的结果表明，遗传对吸烟行为的影响很小。我们对国家科学院-国家研究理事会双胞胎登记处的受试者进行了吸烟行为几个方面的遗传分析。登记册包括1917年至1927年出生在美国的男性双胞胎，他们在第二次世界大战期间是武装部队的成员。4775对双胞胎的吸烟史信息是可用的，他们在1967年至1969年首次调查，当时他们40至50岁，然后在1983年至1985年再次调查，当时他们56至66岁。在这个队列中，80%的受试者在他们的生活中曾经吸烟，60%的人在1967年到1969年吸烟，39%的人在1983年到1985年吸烟。在基线和16年后的第二次随访中，研究了双胞胎吸烟习惯的相似性。通过比较同卵双生子和异卵双生子的吸烟一致性，分析家族和遗传因素对吸烟的相对贡献。在1967-1969年的调查中，对于从不吸烟的双胞胎，同卵双胞胎中观察到的吸烟与预期吸烟的一致性的比率高于异卵双胞胎（总率比，1.38; 95%置信区间，1.25至1.54），对于前吸烟者（总体率比，1.59; 95%置信区间，1.35至1.85），目前吸烟者（总比率，1.18; 95%置信区间，1.11至1.26），以及目前的雪茄或烟斗吸烟者（总体率比，1.60; 95%置信区间，1.22至2.06）。这些数据还表明了基因对戒烟的影响。同卵双胞胎比异卵双胞胎更有可能在戒烟方面保持一致（总体比率，1.24; 95%置信区间，1.06至1.45）。结论。在这个成年男性双胞胎队列中，终生吸烟习惯受到中度遗传影响。
Background. The results of twin and family studies suggest that heredity has a small influence on smoking behavior.Methods. We conducted a genetic analysis of several aspects of smoking behavior among subjects in the National Academy of Sciences-National Research Council Twin Registry. The registry includes male twins who were born in the United States between 1917 and 1927 and who were members of the armed forces during World War II. Information on smoking history was available for 4775 pairs of twins, who were first surveyed in 1967 through 1969, when they were 40 to 50 years old, and then resurveyed in 1983 through 1985, when they were 56 to 66. Eighty percent of the subjects in this cohort had smoked at some time in their lives, 60 percent were smokers in 1967 through 1969, and 39 percent were smoking in 1983 through 1985. Similarities between twins in smoking habits at base line and at the second follow-up 16 years later were examined. The comparison of concordance for smoking between monozygotic and dizygotic twins was used to assess the relative contribution of familial and genetic factors.Results. In the 1967-1969 survey the ratio of observed to expected concordance for smoking was higher among the monozygotic twins than among the dizygotic twins for those who had never smoked (overall rate ratio, 1.38; 95 percent confidence interval, 1.25 to 1.54), for former smokers (overall rate ratio, 1.59; 95 percent confidence interval, 1.35 to 1.85), for current cigarette smokers (overall rate ratio, 1.18; 95 percent confidence interval, 1.11 to 1.26), and for current cigar or pipe smokers (overall rate ratio, 1.60; 95 percent confidence interval, 1.22 to 2.06). The data also suggest genetic influences on quitting smoking. Monozygotic twins were more likely than dizygotic twins to be concordant for quitting smoking (overall rate ratio, 1.24; 95 percent confidence interval, 1.06 to 1.45).Conclusions. In this cohort of adult male twins, there were moderate genetic influences on lifetime smoking practices.