Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh-Lamb equation
Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh-Lamb equation
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DOI：
10.1117/1.jbo.20.2.020501
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发表时间：
2015-02-01
影响因子：
3.5
通讯作者：
Larin, Kirill V.
中科院分区：
文献类型：
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作者：
Han, Zhaolong;Aglyamov, Salavat R.;Larin, Kirill V.
我们证明了使用修改后的瑞利-兰姆频率方程结合非接触式光学相干弹性成像来量化角膜的粘弹性。空气脉冲引起的弹性波的相速度提取的频谱分析和使用瑞利-兰姆频率方程（RLFE）用于计算样品的杨氏模量。在2%琼脂模型（n = 3）上进行验证实验，然后原位应用于猪角膜（n = 3）。估计猪角膜的杨氏模量类似于60 kPa，剪切粘度类似于0.33 Pa。S.结果表明，RLFE是一种很有前途的方法，无创量化的角膜生物力学性能，并可能是有用的临床眼科应用。(C)2015年，美国光电仪器工程师学会（SPIE）
We demonstrate the use of a modified Rayleigh-Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young's moduli of the samples using the Rayleigh-Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n = 3) and then applied to porcine corneas (n = 3) in situ. The Young's moduli of the porcine corneas were estimated to be similar to 60 kPa with a shear viscosity similar to 0.33 Pa . s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)