Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients
Laparoscopic Sleeve Gastrectomy Resolves Low GHRP-2-Stimulated Growth Hormone Levels in Obese Patients
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DOI：
10.1007/s11695-017-2769-4
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发表时间：
2017-08-01
期刊：
影响因子：
2.9
通讯作者：
Yokote, Koutaro
中科院分区：
文献类型：
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作者：
Ohara, Emi;Tokuyama, Hirotake;Yokote, Koutaro
由于肥胖患者生长激素(GH)分泌减少，我们不仅检测了与GH分泌减少相关的因素，还检测了GH释放肽(GHRP)-2负荷试验在腹腔镜胃切除术(LSG)前后的反应。这项研究包括28名年龄在19-65岁之间的人[平均体重指数(BMI)，39.4+/-9.4 kg/m(2)]。在单因素分析中，生长激素分泌峰值与体重指数(r=-0.59，p=0.001)、内脏脂肪组织(r=-0.47，p=0.005)和皮下脂肪组织(r=-0.40，p=0.04)呈负相关。在这两名肥胖患者中，LSG治疗12个月后体重减轻，对GHRP-2负荷试验的反应明显改善。综上所述，肥胖症患者GH分泌减少，经LSG治疗后有所改善。
Because growth hormone (GH) secretion is reportedly decreased in obese patients, we examined not only the factors associated with the decreased GH secretion but also GH response to the GH-releasing peptide (GHRP)-2-load test before and after laparoscopic gastrectomy (LSG). The study comprised 28 individuals aged 19-65 years [mean body mass index (BMI), 39.4 +/- 9.4 kg/m(2)]. In the univariate analysis, GH secretion peaks correlated negatively with BMI (r = -0.59, p = 0.001), visceral adipose tissue (r = -0.47, p = 0.005), and subcutaneous adipose tissue (r = -0.40, p = 0.04). In the two obese patients, the response to the GHRP-2-load test markedly improved by weight loss 12 months after LSG. In conclusion, GH secretion was decreased in obese patients and improved by LSG.