Roles of RUNX in Hypoxia-Induced Responses and Angiogenesis
Roles of RUNX in Hypoxia-Induced Responses and Angiogenesis
复制标题
DOI：
10.1007/978-981-10-3233-2_27
复制
发表时间：
2017-01-01
期刊：
影响因子：
--
通讯作者：
Lee, You Mie
中科院分区：
文献类型：
--
作者：
Lee, Sun Hee;Manandhar, Sarala;Lee, You Mie
在过去的二十年中，人们对 Runt 结构域转录因子（RUNX1、2 和 3）的功能、结构元件、遗传变异以及在正常发育和病理条件下的作用进行了研究。从果蝇到哺乳动物，Runt 家族蛋白在进化上是保守的，这强调了它们的生理重要性。在发育中的器官、生长中的肿瘤以及由于血管损伤或阻塞而变得缺血的组织中经常观察到由血液供应不足引起的缺氧微环境。在胚胎发育和肿瘤生长过程中，缺氧会引发应激反应，通过增加红细胞生成和血管生成并引发代谢变化来克服低氧条件。本文简要介绍了缺氧条件和细胞反应，以及血管生成及其相关信号通路，然后介绍了我们目前对Runx家族蛋白在缺氧反应，特别是血管生成中的功能和分子机制的认识。
During the past two decades, Runt domain transcription factors (RUNX1, 2, and 3) have been investigated in regard to their function, structural elements, genetic variants, and roles in normal development and pathological conditions. The Runt family proteins are evolutionarily conserved from Drosophila to mammals, emphasizing their physiological importance. A hypoxic microenvironment caused by insufficient blood supply is frequently observed in developing organs, growing tumors, and tissues that become ischemic due to impairment or blockage of blood vessels. During embryonic development and tumor growth, hypoxia triggers a stress response that overcomes low-oxygen conditions by increasing erythropoiesis and angiogenesis and triggering metabolic changes. This review briefly introduces hypoxic conditions and cellular responses, as well as angiogenesis and its related signaling pathways, and then describes our current knowledge on the functions and molecular mechanisms of Runx family proteins in hypoxic responses, especially in angiogenesis.