Pharmacological modulation of learning-induced plasticity in human auditory cortex.
Pharmacological modulation of learning-induced plasticity in human auditory cortex.
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发表时间：
2007
影响因子：
2.8
通讯作者：
C. Thiel
中科院分区：
文献类型：
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作者：
C. Thiel
来自动物和人类的证据表明，初级听觉皮层以一种依赖于经验的方式不断重塑。初级听觉皮层的重组可以在感受野、地形图和用神经影像学方法测量的脑激活水平上观察到。几个神经调节系统被证明有助于这种经验依赖性重组。方法：本文综述了胆碱能、去甲肾上腺素能、多巴胺能和多巴胺能对学习、经验和损伤诱导的听觉皮层可塑性的调节。结果：关于学习诱发的听觉皮层可塑性，大多数研究调查了胆碱能系统的作用，并表明ACh是这种形式的快速可塑性所必需的。然而，也有证据表明，儿茶酚胺、多巴胺和去甲肾上腺素可能有助于学习和经验引起的听觉皮层变化。结论我认为，现有的胆碱能和去甲肾上腺素能可塑性调节的实验数据提供了一个有希望的基础，潜在的药物干预，以帮助恢复听觉功能。
PURPOSE Converging evidence from animals and humans indicate that the primary auditory cortex is continuously reshaped in an experience-dependent way. Reorganisation in primary auditory cortex can be observed at the level of receptive fields, topographic maps and brain activations measured with neuroimaging methods. Several neuromodulatory systems were shown to contribute to such an experience-dependent reorganization. METHODS This paper reviews evidence addressing the cholinergic, noradrenergic, dopaminergic and serotonergic modulation of learning-, experience-, and injury-induced plasticity in the auditory cortex. RESULTS Regarding learning-induced plasticity in the auditory cortex most studies have investigated the role of the cholinergic system and shown that ACh is essential for this form of rapid plasticity. Nevertheless there is also evidence that the catecholamines dopamine and noradrenaline might contribute to learning- and experience-induced changes in the auditory cortex. CONCLUSIONS I suggest, that the available experimental data on cholinergic and noradrenergic modulation of plasticity offers a promising basis for potential pharmacological interventions to aid recovery of aural functions.