ANIMAL-MODELS FOR ASSESSING DRUGS OF ABUSE
ANIMAL-MODELS FOR ASSESSING DRUGS OF ABUSE
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DOI：
10.1016/s0149-7634(05)80089-2
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发表时间：
1991-03-01
影响因子：
8.2
通讯作者：
BRADY, JV
中科院分区：
文献类型：
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作者：
BRADY, JV
限制药物临床有效性的一个主要毒性作用是它们对非医疗使用的敏感性和相当一部分人群的滥用。 主要的研究工作已经指向开发更安全和更有效的治疗剂，不会受到这样的滥用，实验室动物评估模型有重要贡献的评价这样的化合物。 现在有几种证据可以证明，根据这种动物实验室模型得出的关于人类药物滥用责任的观察结果是可靠的，具有广泛的普遍性。 表征这种动物评估模型和人类药物滥用竞技场之间相互作用的最重要的接触点是药物的生化/药理学/毒性特性与其环境/行为刺激功能之间的关系。 由于动物模型研究技术的这些发展和随之而来的药物作用知识的进步，已经为重新定义一系列令人困惑的现象和经验性伪现象提供了操作基础，这些现象和伪现象与“成瘾”、“依赖”和“滥用”等术语大致相同。"
A major toxic effect that has limited the clinical usefulness of medicinal drugs has been their susceptibility to nonmedical use and abuse by significant segments of the population. Major research efforts have been directed toward the development of safer and more effective therapeutic agents that would not be subject to such misuse, and laboratory animal assessment models have contributed importantly to the evaluation of such compounds. There are now several converging lines of evidence that testify to the reliability and broad generality of observations concerning drug abuse liability in humans based upon such animal laboratory models. The most important point of contact that characterizes the interaction between such animal assessment models and the human drug abuse arena is the demonstrated relationship between the biochemical/pharmacological/toxic properties of drugs on the one hand, and their environmental/behavioral stimulus functions on the other. As a result of these developments in animal model research technology and the consequent advances in knowledge of drug action, an operational basis has been provided for redefining the bewildering range of phenomena and experiential pseudo-phenomena loosely identify with such terms as "addiction," "dependence" and "abuse."