Relation between neuroradiological findings and upper limb function in hemiplegic cerebral palsy
Relation between neuroradiological findings and upper limb function in hemiplegic cerebral palsy
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DOI：
10.1016/j.ejpn.2009.01.004
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发表时间：
2010-03-01
影响因子：
3.1
通讯作者：
De Cock, Paul
中科院分区：
文献类型：
--
作者：
Feys, Hilde;Eyssen, Maria;De Cock, Paul
本文对53例偏瘫性脑瘫（CP）患儿的神经影像学表现与上肢功能的关系进行了探讨。将患儿的CT和MRI图像分为畸形、脑室周围病变、先天性皮质-皮质下病变和后天获得性病变4组。临床评估包括活动度测量（单侧上肢功能墨尔本评估和House分类）和身体功能测量（运动和感觉障碍）采用比较统计和相关分析3例患儿有畸形，28例患儿有心室周围病变。1例皮质-皮质下病变，8例后天获得性病变，脑室周围病变患儿运动功能最好。单纯脑室周围病变患儿的表现明显优于混合病变患儿，先天性皮质-皮层下病变与后天病变患儿的表现差异不显著。结果进一步表明，大脑中动脉梗死和基底节区/丘脑病变与较差的表现显著相关。这些见解对预后有价值，并可能有助于更好地描述治疗干预措施(C) 2009年欧洲儿科神经病学学会出版，Elsevier Ltd版权所有
The relation between neuroradiological findings and upper limb function was examined in 53 children with hemiplegic cerebral palsy (CP) CT and MRI images of the children were classified into four groups (malformations, periventricular lesions, congenital cortical-subcortical lesions and postnatally acquired lesions) Additionally, each single affected neuroanatomical structure was noted Clinical assessments included measures of activity (Melbourne Assessment of Unilateral Upper Limb Function and House Classification) and body functions (motor and sensory impairments) Comparative statistics and correlation analysis were Used Three children had a malformation, 28 a periventricular lesion, 1.4 a cortical-subcortical lesion and eight a postnatally acquired lesion Children with periventricular lesions obtained the best motor functioning Within this group, children with pure periventricular lesions performed significantly better compared to mixed lesions The differences between congenital cortical-subcortical lesions and acquired lesions were not significant Results further showed that middle cerebral artery infarctions and basal ganglia/thalamic lesions were significantly correlated to a worse performance The type of lesion determined by the timing of the brain insult, and the location of the lesion distinguish children with hemiplegic CP regarding upper limb function These insights are valuable for prognosis and may contribute Loa better delineation of therapeutic interventions (C) 2009 European Paediatric Neurology Society Published by Elsevier Ltd All rights reserved