Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma.
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma.
复制标题
在体外放射增敏 U251 细胞和颅内神经胶质瘤小鼠模型中，银纳米颗粒的表现优于金纳米颗粒。
DOI：
10.2147/ijn.s115473
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发表时间：
2016
影响因子：
8
通讯作者：
Gu N
中科院分区：
文献类型：
--
作者：
Liu P;Jin H;Guo Z;Ma J;Zhao J;Li D;Wu H;Gu N
放射治疗在癌症的治疗中起着重要的作用，但肿瘤细胞对放射的抵抗仍然是一个严重的问题。迫切需要对更有效的放射增敏剂进行更多的研究，以克服这种耐药性，从而改善治疗结果。本研究的目的是评估和比较金纳米粒子（AuNPs）和银纳米粒子（AgNPs）在临床相关兆伏能量下对胶质瘤的放射增敏效果。AuNPs和AgNPs都增强了辐射的体外和体内抗胶质瘤作用。在相同质量和摩尔浓度下，AgNPs比AuNPs具有更强的放射增敏能力，导致更高的凋亡细胞死亡率。此外，与AuNP加辐射相比，AgNP与辐射的组合显著增加了自噬水平。这些研究结果表明，银纳米粒子作为一种高效的纳米放射增敏剂治疗胶质瘤的潜在应用。
Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma.