Proceedings from the Society of Interventional Radiology research consensus panel on critical limb ischemia.

Proceedings from the Society of Interventional Radiology research consensus panel on critical limb ischemia.
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介入放射学会关于严重肢体缺血研究共识小组的会议记录。

DOI:
10.1016/j.jvir.2012.10.028
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发表时间:
2013
期刊:
Journal of vascular and interventional radiology : JVIR
影响因子:
--
通讯作者:
Rosenfield,Kenneth
Rosenfield,Kenneth
中科院分区:
--
文献类型:
--
作者:
Misra,Sanjay;Lookstein,Robert;Rundback,John;Hirsch,AlanT;Hiatt,WilliamR;Jaff,MichaelR;White,ChristopherR;Conte,Michael;Geraghty,Patrick;Patel,Manesh;Rosenfield,Kenneth

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BackgroundIn the United States, it is estimated that 5–12 million people have peripheral arterial disease (PAD)(1). The prevalence of PAD increases with age and is estimated to afflict 4.3% of the population over 40 years of age and 14.5% of those over 70 (2). Depending on the severity and extent of the disease, patients may be asymptomatic or present with clinical symptoms including atypical leg pain, classic intermittent claudication, acute limb ischemia, or chronic critical limb ischemia. The incidence of critical limb ischemia (CLI) is 500–1000 patients per million in the western world [2]. The natural history of patients with CLI is poor (25% mortality and 30% amputation rate at 1 year)(3–5). Patients with critical limb ischemia (CLI) have advanced atherosclerosis involving all cardiovascular beds and thus have 5-year mortality greater than patients with symptomatic coronary arterial disease. Although the precise mechanisms associated with these high mortality and amputation rates is not known, individuals with CLI are known to suffer from a increased rates of comorbidities, including poorly controlled atherosclerosis risk factors (such as smoking, diabetes, hypertension and hypercholesterolemia), advanced chronic kidney disease, and coronary artery disease (6).
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