Impaired Generalization of Associative Learning in Patients with Alcohol Dependence After Intermediate-term Abstinence
Impaired Generalization of Associative Learning in Patients with Alcohol Dependence After Intermediate-term Abstinence
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DOI：
10.1093/alcalc/ags050
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发表时间：
2012-09-01
影响因子：
2.8
通讯作者：
Kelemen, Oguz
中科院分区：
文献类型：
--
作者：
Mattyassy, Adrienne;Keri, Szabolcs;Kelemen, Oguz
目的：我们使用联想学习任务，以调查酒精依赖的认知功能障碍。该测试适用于评估与内侧颞叶功能相关的刺激-反应学习和记忆泛化（获得性等效）。方法：20例戒酒6个月以上的酒依赖患者和20例健康对照者参加本研究。在任务中，前件刺激是卡通面孔（女孩，男孩，男人和女人）和随后的刺激是彩色卡通鱼。这项任务是通过反馈来学习脸鱼的关联。在转移阶段，鱼脸对被推广到新的协会。结果：在鱼脸联想的获得阶段，患者和对照组之间没有显著差异。在转移阶段，患者相对于对照组受损。我们没有发现任务表现和智商之间的联系。结论：这些结果表明，戒酒的酒精依赖患者显示出显着的功能障碍，概括的协会，这可能表明功能障碍的内侧颞叶。
Aims: We used an associative learning task in order to investigate cognitive dysfunctions in alcohol dependence. This test is suitable for the assessment of stimulus-response learning and memory generalization (acquired equivalence), which is related to medial temporal lobe functioning. Methods: Twenty patients with alcohol dependence (abstinence: > 6 months) and 20 matched healthy controls participated in the study. In the task, antecedent stimuli were cartoon faces (girl, boy, man and woman) and consequent stimuli were color cartoon fishes. The task was to learn face-fish associations using feedback. In the transfer phase, the fish-face pairs were generalized to new associations. Results: There was no significant difference between patients and controls during the acquisition phase of fish-face associations. In the transfer phase, patients were impaired relative to controls. We found no association between task performance and intelligence quotient. Conclusion: These results suggest that abstinent patients with alcohol dependence show marked dysfunctions in the generalization of associations, which may indicate the dysfunction of the medial temporal lobe.