Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization.: Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging
Relaxometric and magnetic characterization of ultrasmall iron oxide nanoparticles with high magnetization.: Evaluation as potential T1 magnetic resonance imaging contrast agents for molecular imaging
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DOI：
10.1021/la063415s
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发表时间：
2007-04-10
期刊：
影响因子：
3.9
通讯作者：
Muller, Robert N.
中科院分区：
文献类型：
--
作者：
Taboada, Elena;Rodriguez, Elisenda;Muller, Robert N.
在这里，我们报告的超小γ-Fe 2 O3纳米粒子（5 nm）的合成呈现出非常窄的粒度分布和异常高的饱和磁化强度。该合成是通过在有机介质中分解铁有机金属前体来进行的。随后，在生理pH值的水溶液中的颗粒稳定，和胶体分散体已被彻底的互补技术的特点。特别注意的是，通过透射电子显微镜，X-射线衍射，动态光散射，磁性和弛豫测量的平均粒径的评估。在不同技术之间发现的良好一致性表明了非常窄的粒度分布。关于磁性，颗粒在室温下是超顺磁性的，并且呈现出异常高的饱和磁化强度值。此外，我们描述了这些颗粒作为磁共振分子成像的特异性阳性造影剂的潜力。
Here we report on the synthesis of ultrasmall gamma-Fe2O3 nanoparticles (5 nm) presenting a very narrow particle size distribution and an exceptionally high saturation magnetization. The synthesis has been carried out by decomposition of an iron organometallic precursor in an organic medium. The particles were subsequently stabilized in an aqueous solution at physiological pH, and the colloidal dispersions have been thoroughly characterized by complementary techniques. Particular attention has been given to the assessment of the mean particle size by transmission electron microscopy, X-ray diffraction, dynamic light scattering, magnetic, and relaxometric measurements. The good agreement found between the different techniques points to a very narrow particle size distribution. Regarding the magnetic properties, the particles are superparamagnetic at room temperature and present an unusually high saturation magnetization value. In addition, we describe the potential of these particles as specific positive contrast agents for magnetic resonance molecular imaging.