Organochlorine insecticides in substantia nigra in Parkinson's disease
Organochlorine insecticides in substantia nigra in Parkinson's disease
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DOI：
10.1080/009841000156907
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发表时间：
2000-02-25
期刊：
影响因子：
--
通讯作者：
Mann, D
中科院分区：
文献类型：
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作者：
Corrigan, FM;Wienburg, CL;Mann, D
比较了帕金森病（PD）患者黑质（SN）中有机氯（OC）化合物的浓度与皮质路易体痴呆（CLBD）、阿尔茨海默病（AD）和非痴呆非帕金森对照（CON）患者脑中有机氯（OC）化合物的浓度。帕金森病组织中六氯环己烷的γ异构体（γ HCH，林丹）水平（平均值+/-标准差：0.56 +/- 0.434微克/克脂质）明显高于其他三组（CLBD 0.052 +/- 0.434微克/克脂质）。101 μ g/g脂质;未检测到AD; CON 0.125 +/- 0.195：与PD的所有差异在p <0.05时显著，Mann-Whitney U-检验）。PD脑中的狄氏剂（HEOD）高于AD或对照脑，而1，1 '-（2，2-二氯乙烯基二烯）-双（4-氯苯）（p，p-DDE）和总Aroclor匹配的多氯联苯（匹配的PCB）仅在PD黑质中高于CLBD。这些研究结果并不与来自流行病学工作和动物研究的假设，有机氯杀虫剂产生的黑质多巴胺能束的直接毒性作用，并可能有助于发展PD的那些由于细胞色素P-450多态性，过度暴露，或其他因素而变得敏感。
The concentrations of organochlorine (OC) compounds in the substantia nigra (SN) were compared in Parkinson's disease (PD) with concentrations in brain from cortical Lewy body dementia (CLBD), Alzheimer's disease (AD), and nondemented nonparkinsonian controls (CON). The levels of the gamma isomer of hexachlorocyclohexane (gamma HCH, lindane) were significantly higher in PD tissues (mean +/- SD: 0.56 +/- 0.434 mu g/g lipid) than in the other three groups (CLBD 0.052 +/- 0. 101 mu g/g lipid; AD none detected; CON 0.125 +/- 0.195: all differences from PD significant at p < .05, Mann-Whitney U-test). Dieldrin (HEOD) was higher in PD brain than in AD or control brain, while 1, 1'-(2,2-dichloroethenyl diene)-bis(4-chlorobenzene) (p,p-DDE) and total Aroclor-matched polychlorinated biphenyls (matched PCBs) were only higher in PD substantia nigra when these concentrations were compared with those of CLBD. These findings are not inconsistent with the hypothesis derived from epidemiological work and animal studies that organochlorine insecticides produce a direct toxic action on the dopaminergic tracts of the substantia nigra and may contribute to the development of PD in those rendered susceptible by virtue of cytochrome P-450 polymorphism, excessive exposure, or other factors.