Inhibition of Water-Evoked Swallowing During Noxious Mechanical Stimulation of Tongue in Anesthetized Rats
Inhibition of Water-Evoked Swallowing During Noxious Mechanical Stimulation of Tongue in Anesthetized Rats
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麻醉大鼠舌头有毒机械刺激过程中水诱发吞咽的抑制
DOI：
10.1007/s00455-022-10522-5
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发表时间：
2022
期刊：
影响因子：
2.6
通讯作者：
Inoue Makoto
中科院分区：
文献类型：
--
作者：
Tsujimura Takanori;Nakajima Yuta;Chotirungsan Titi;Kawada Satomi;Tsutsui Yuhei;Yoshihara Midori;Suzuki Taku;Nagoya Kouta;Magara Jin;Inoue Makoto
吞咽困难有时伴有疼痛。由于口面结构有助于咀嚼和吞咽，口面疼痛可能会损害这两个功能。咬舌不仅可能在进食时意外发生，也可能在某些病理条件下发生。然而，目前还不清楚舌头的有害机械刺激是否会影响吞咽。为了探讨这个问题，我们评估了舌捏刺激对以5.0 µL/s的流速向麻醉大鼠咽喉区域输注蒸馏水（DW）20 s诱发吞咽起始的影响。吞咽反射通过舌骨上肌（包括二腹肌的前腹、下颌舌骨肌和颏舌骨肌）的肌电图（EMG）爆发以及通过目视检查的喉部提升来识别。在捏刺激期间的DW诱发的吞咽的数量显着小于在控制条件下或在压力刺激期间。在捏刺激的第一次吞咽的起始潜伏期显着长于在控制条件。与对照组相比，双侧上级喉神经（SLN）切断后，DW诱发的吞咽几乎被取消，这表明SLN在DW诱发的吞咽的启动中起着至关重要的作用。最后，电生理数据表明，一些SLN反应神经元在孤束核（nTS）表现出延迟的潜伏期从一个单一的SLN刺激在舌捏刺激。这些结果表明，有害的机械刺激的舌头抑制吞咽的启动和调制的nTS神经元的活动。
Dysphagia is sometimes accompanied by pain. Because orofacial structures subserve mastication and swallowing, orofacial pain might impair both functions. Tongue biting can occur not only accidentally while eating but also in some pathological conditions. However, it remains unclear whether noxious mechanical stimulation of the tongue affects swallowing. To explore this question, we evaluated the effects of lingual pinch stimulation on the initiation of swallowing evoked by distilled water (DW) infusion with a flow rate of 5.0 µL/s for 20 s into the pharyngolaryngeal region in anesthetized rats. The swallowing reflex was identified by electromyographic (EMG) bursts in the suprahyoid muscles which include the anterior belly of the digastric muscle, mylohyoid and geniohyoid muscles, and laryngeal elevation by visual inspection. The number of DW-evoked swallows during pinch stimulation was significantly smaller than that in a control condition or during pressure stimulation. The onset latency of the first swallow during pinch stimulation was significantly longer than that in the control condition. DW-evoked swallowing was almost abolished following bilateral transection of the superior laryngeal nerve (SLN) compared with the control condition, suggesting that the SLN plays a crucial role in the initiation of DW-evoked swallowing. Finally, electrophysiological data indicated that some SLN-responsive neurons in the nucleus tractus solitarii (nTS) exhibited delayed latency from a single SLN stimulation during lingual pinch stimulation. These results suggest that noxious mechanical stimulation of the tongue inhibits the initiation of swallowing and modulates neuronal activity in the nTS.
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DOI：
10.1054/ijom.2001.0190
发表时间：
2002-04-01
影响因子：
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作者：
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