Hyperprolactinemia following chronic alcohol administration.
Hyperprolactinemia following chronic alcohol administration.
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长期饮酒后出现高催乳素血症。
DOI：
10.1159/000318492
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发表时间：
2010
影响因子：
--
通讯作者：
Sarkar,DipakK
中科院分区：
文献类型：
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作者：
Sarkar,DipakK
有几份报告表明，酗酒的男性和女性体内存在高水平的催乳素(PRL)。酒精引起的高催乳素血症也在非人类灵长类动物和实验动物中被证明。因此，临床数据和动物数据表明，酒精摄入是高催乳素血症的积极危险因素。在动物研究中，人们发现长期服用乙醇不仅会升高血浆催乳素水平，而且还会增加脑下垂体促乳素的增殖。乙醇对催乳素的作用包括与雌激素反应的信号级联或雌激素调节的细胞间通讯的串扰。此外，它还涉及抑制多巴胺D2受体、抑制G蛋白和细胞内环磷酸腺苷(CAMP)、调节转化生长因子-β(转化生长因子-β)亚型及其受体(T-βRII)，以及转化生长因子-β(β)作用的继发性因子，包括毛囊-星状细胞产生β-成纤维细胞生长因子(b-β)。调控b-成纤维细胞生长因子产生和分泌的下游信号涉及依赖于MAP的p44/42通路的激活。协同抑制D2受体和Tβ受体介导的信号转导以及增强碱性成纤维细胞生长因子的活性可能是乙醇对催乳素的产生和细胞增殖的关键作用。版权所有(C)2010 S.Karger AG，巴塞尔
There are several reports showing evidence for the existence of high levels of prolactin (PRL) in alcoholic men and women. Alcohol-induced hyperprolactinemia has also been demonstrated in nonhuman primates and laboratory animals. Therefore, the clinical data as well as animal data suggest that ethanol consumption is a positive risk factor for hyperprolactinemia. In animal studies, it was found that chronic ethanol administration not only elevates plasma levels of PRL but also increases proliferation of pituitary lactotropes. Ethanol action on lactotropes involves crosstalk with estradiolresponsive signaling cascade or estradiol-regulated cell-cell communication. Additionally, it involves suppression of dopamine D2 receptors inhibition of G proteins and intracellular cyclic adenosine monophosphate (cAMP), modulation of transforming growth factor-beta (TGF-β) isoforms and their receptors (TβRII), as well as factors secondary to TGF-β actions, including production of beta-fibroblast growth factor (bFGF) from follicular-stellate cells. The downstream signaling that governs b-FGF production and secretion involves activation of the MAP kinase p44/42-dependent pathway. A coordinated suppression of D2 receptor-and TβRII receptor-mediated signaling as well as enhancement of bFGF activity might be critical for ethanol action on PRL production and cell proliferation in lactotropes. Copyright© 2010 S. Karger AG, Basel