Re-framing microbicide acceptability: findings from the MDP301 trial
Re-framing microbicide acceptability: findings from the MDP301 trial
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DOI：
10.1080/13691051003736261
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Pool, Robert
中科院分区：
文献类型：
--
作者：
Montgomery, Catherine M.;Gafos, Mitzy;Pool, Robert
杀菌剂通常是在疾病预防框架内概念化的，研究通常根据产品特性、使用意愿和风险降低来定义可接受性。这一出发点导致了关于杀微生物剂的假设，这些假设并没有受到实证研究的挑战，而是倾向于排除数据和随后的概念模型。很少有研究采取主流（“内部”）视角或试图了解杀菌剂如何融入更广泛的女性和男性日常生活背景。作为 MDP301 III 期杀菌剂试验综合社会科学部分的一部分，我们对南非、赞比亚、坦桑尼亚和乌干达的女性试验参与者进行了深入访谈。女性使用凝胶的经历挑战了人们经常重申的关于杀菌剂的几个假设。我们的分析表明，当前的定义和概念框架没有充分解释女性赋予凝胶的含义范围。即使在临床试验的背景下，也有可能根据女性的实践和主位解释获得更丰富的、人种学的和跨文化的可接受性概念。我们现在需要超越有限的可接受性概念，并考虑杀菌剂如何适应女性和男性性行为和性健康的更全面的情况。
Microbicides are most usually conceptualised within a disease prevention framework and studies usually define acceptability in terms of product characteristics, willingness to use and risk reduction. This starting point has led to assumptions about microbicides which, rather than being challenged by empirical studies, have tended to foreclose the data and subsequent conceptual models. Few studies take an emic ('insider') perspective or attempt to understand how microbicides fit into the broader context of women's and men's everyday lives. As part of the integrated social science component of the MDP301 Phase III microbicide trial, in-depth interviews were conducted with female trial participants in South Africa, Zambia, Tanzania and Uganda. Women's experiences of the gel challenge several assumptions that have commonly been reiterated about microbicides. Our analysis suggests that current definitions and conceptual frameworks do not adequately account for the range of meanings that women attribute to gel. Even within the context of a clinical trial, it is possible to obtain a richer, ethnographic and cross-cultural concept of acceptability based on women's practice and emic interpretations. We now need to move beyond limited notions of acceptability and consider how microbicides fit into a more holistic picture of women's and men's sexuality and sexual health.