Impact of childhood trauma on sensorimotor gating in Chinese patients with chronic schizophrenia
Impact of childhood trauma on sensorimotor gating in Chinese patients with chronic schizophrenia
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DOI：
10.1016/j.psychres.2018.01.037
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发表时间：
2018-05
影响因子：
11.3
通讯作者：
Xianbin Li;Qing Tian;Qijing Bo;Guangping Zhang;Wei Zheng;Yu-jie Wen;Yilang Tang;Chuanyue Wang
中科院分区：
文献类型：
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作者：
Xianbin Li;Qing Tian;Qijing Bo;Guangping Zhang;Wei Zheng;Yu-jie Wen;Yilang Tang;Chuanyue Wang
我们调查了中国慢性精神分裂症患者的儿童期创伤（CT）和感觉运动门控之间的关系。采用儿童创伤量表（CTQ-SF）对75例患者进行评估，然后采用改进的感知空间分离诱导的前脉冲抑制（PSS PPI）和感知空间共位PPI（PSC PPI或经典PPI）测试感觉运动门控。令人吃惊的刺激（90分贝）单独或之前的离散前脉冲刺激4分贝的背景60分贝的噪音水平。对CT和各种PPI范例之间的关联进行统计学分析。单因素分析显示，CT和PPI范例之间无显著相关性（p> 0.05）。然而，多元线性回归分析显示，性虐待和阳性和阴性症状量表（PANSS）评分与PSS PPI呈负相关（p= 0.029和0.008，分别）。另一方面，女性性别和吸烟史与PSS PPI呈正相关（分别为p= 0.044和0.043）。总之，本研究的结果表明，CT可以是一个诱发因素，影响感觉运动门在精神分裂症患者。
We investigated the relationship between childhood trauma (CT) and sensorimotor gating in Chinese patients diagnosed with chronic schizophrenia. Seventy-five patients were assessed with the Childhood Trauma Questionnaire-Short Form (CTQ-SF), and then the modified paradigm, perceived spatial separation-induced prepulse inhibition (PSS PPI) and the perceived spatial co-location PPI (PSC PPI or classical PPI) were applied to test sensorimotor gating. Startling stimuli (90 dB) were presented either alone or preceded by discrete prepulse stimuli of 4 dB in a background 60-dB noise level. Associations between CT and various PPI paradigms were statistically analyzed. Univariate analysis revealed the absence of a significant correlation between CT and PPI paradigms (p> 0.05). However, multiple linear regression analyses revealed that sexual abuse and the positive and negative syndrome scale (PANSS) score were negatively correlated with PSS PPI (p= 0.029 and 0.008, respectively). On the other hand, female sex and history of smoking were positively correlated with PSS PPI (p= 0.044 and 0.043, respectively). In conclusion, the results of this study suggest that CT can be a predisposing factor that affects sensorimotor gating in schizophrenia patients.