Characteristics of human papillomaviruses infection in men with genital warts in Shanghai.
Characteristics of human papillomaviruses infection in men with genital warts in Shanghai.
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DOI：
10.18632/oncotarget.9708
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发表时间：
2016-08-16
期刊：
影响因子：
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通讯作者：
Tang Y
中科院分区：
文献类型：
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作者：
Chen X;Li L;Lai Y;Liu Q;Yan J;Tang Y
人乳头瘤病毒（HPV）感染的男性导致HPV继续传播给女性。对935例男性生殖器疣患者进行了15种高危型HPV（HPV 16、18、31、33、35、39、45、51、52、53、56、58、59、66和68）和6种低危型HPV（HPV 6、11、42、43、44和CP 8304）的流行病学调查。在447例（447/935，47.8%）HPV DNA阳性者中，高危型HPV感染230例（24.6%），低危型HPV感染356例（38.1%），高低危型HPV同时感染139例（14.9%）。356例低危型HPV感染者中，333例（93.5%）为单一HPV株感染; HPV基因型6、11、CP 8304、44分别为203例（57.0%）、147例（41.3%）、24例（6.7%）、5例（1.4%）;年龄≤ 20岁人群感染率最高。高危型HPV在我院感染者中也有较高的检出率，基因型16、58、51、39、52和53为前5位，感染率分别为27.4%、18.7%、14.3%、13.9%、12.6%和12.6%，仅有68.3%的受试者为单一感染; 41岁≤ 50岁的受试者感染率最高。高危型和低危型HPV均在男性生殖器疣患者中高度流行，其对女性HPV控制和预防的影响有待进一步评估。
Human papillomaviruses (HPV) infected men causes continued transmission of HPV to women. The prevalence of 15 high-risk HPV strains (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68) and 6 low-risk HPV strains (HPV6, 11, 42, 43, 44 and CP8304) were evaluated in 935 males with genital warts. Of the 447 (447/935, 47.8%) HPV DNA positive subjects, 230 (24.6%), 356 (38.1%) and 139 (14.9%) were infected by high-risk, low-risk and both high and low-risk HPV respectively. Of the 356 low-risk HPV infected subjects, 333(93.5%) were infected by single HPV strain; 203 (57.0%), 147 (41.3%), 24 (6.7%) and 5 (1.4%) were infected with HPV genotype 6, 11, CP8304 and 44 respectively; population with age ≤ 20 showed the highest infection rate. High-risk HPV are also highly prevalent in our patients, genotype 16, 58, 51, 39, 52 and 53 are the top five prevalent genotypes with infection rates of 27.4%, 18.7%, 14.3%, 13.9%, 12.6% and 12.6% respectively; only 68.3% subjects were sole infection; subjects with 41 ≤ age ≤ 50 showed the highest infection rate. Both high and low-risk HPV are highly prevalent in men with genital warts, its impact on women HPV control and prevention need further evaluation.