Prostaglandin E2-induced release of luteinizing hormone-releasing factor (LRF).
Prostaglandin E2-induced release of luteinizing hormone-releasing factor (LRF).
复制标题
前列腺素 E2 诱导黄体生成素释放因子 (LRF) 的释放。
作者：
S. Ojeda;J. E. Wheaton;S. Mccann
前列腺素E2 （PGE2）注射到意识切除卵巢的大鼠的第三脑室（3rd V），在注射后1,3和5min显示可检测的免疫可测LRF水平的血浆样品的百分比增加。这个百分比在2和4分钟时很小。在静脉注射PGE2并在5分钟后斩首的动物中测量血浆LRF和LH滴度，LRF和LH均显著高于稀释剂注射动物的对照组。这些结果表明，PGE2作用于下丘脑，诱导LRF的释放，其量足以通过外周血浆中直接测量这种神经激素来检测。
Prostaglandin E2 (PGE2) injected into the third ventricle (3rd V) of conscious ovariectomized rats bearing a permanent jugular cannula increased the percentage of plasma samples showing detectable immunoassayable LRF levels at 1, 3 and 5 min after injection. This percentage was small at 2 and 4 min. When plasma LRF and LH titers were measured in animals injected intraventicularly with PGE2 and decapitated 5 min later, both LRF and LH were significantly higher than control values of diluent-injected animals. These results indicate that PGE2 is acting on the hypothalamus to induce release of LRF sufficient in mangitude to be detected by measuring this neurohormone directly in peripheral plasma.