Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy
Adjuvant effects of fermented red ginseng extract on advanced non-small cell lung cancer patients treated with chemotherapy
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DOI：
10.1007/s11655-015-2146-x
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发表时间：
2017-05-01
影响因子：
2.9
通讯作者：
Kang, Shin-Jyung
中科院分区：
文献类型：
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作者：
Jiang Shu-long;Liu Hong-jie;Kang, Shin-Jyung
为探讨发酵红参提取物(FRG)对非小细胞肺癌(NSCLC)化疗的辅助疗效，采用随机数字表法将60例晚期NSCLC患者分为吉西他滨+顺铂(GP)化疗组(26例)和FRG+GP化疗组(34例)，疗程均为60d。采用疲劳症状自评量表、中医症状评分、焦虑自评量表、抑郁自评量表、卡诺夫斯基功能状态量表、癌症治疗肺功能评定量表对患者进行评定。对于化疗后的NSCLC患者，FRG提取物能显著改善患者的FSI评分、CM症状评分、心理状态、身体状况和生活质量，降低化疗毒性，但癌胚抗原、细胞角蛋白-19片段和神经元特异性烯醇化酶的表达水平在单纯化疗组和FRG+化疗组之间以及治疗前后均无显著差异。更大样本量的进一步研究将验证目前的发现。
To investigate the adjuvant therapeutic effects of fermented red ginseng (FRG) extract on non-small cell lung cancer (NSCLC) patients treated with chemotherapy.A total of 60 patients with advanced NSCLC were divided into two groups using a random number table, i.e., the gemcitabine plus cisplatin (GP) chemotherapy alone group (26 patients) and the FRG + GP chemotherapy group (34 patients), for 60-day treatment. Patients were then assessed according to the Fatigue Symptom Inventory, Chinese medicine symptoms score, Self-Rating Anxiety Scale, Self-Rating Depression Scale, Karnofsky Performance Status Scale, and Functional Assessment of Cancer Therapy-Lung. In addition, chemotherapy toxicity and tumor biomarkers were measured.For NSCLC patients after chemotherapy, FRG extract significantly improved the FSI score, CM symptoms score, psychological status, physical conditions, and quality of life and reduced chemotherapy toxicity, but the expression levels of carcinoembryonic antigen, cytokeratin-19 fragments, and neuron-specific enolase were not significantly different between the chemotherapy alone and the FRG + chemotherapy groups or between pre- and post-treatments.This study demonstrated that FRG extract had an adjuvant effect on advanced NSCLC patients treated with chemotherapy. Further studies with a larger sample size will verify the current findings.