Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina.
Flavonoid Naringenin Attenuates Oxidative Stress, Apoptosis and Improves Neurotrophic Effects in the Diabetic Rat Retina.
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DOI：
10.3390/nu9101161
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发表时间：
2017-10-24
期刊：
影响因子：
5.9
通讯作者：
Ola MS
中科院分区：
文献类型：
--
作者：
Al-Dosari DI;Ahmed MM;Al-Rejaie SS;Alhomida AS;Ola MS
糖尿病视网膜病变（DR）是世界范围内视力下降和失明的主要原因之一。糖尿病诱导的氧化应激被认为是引发糖尿病视网膜神经元损伤导致DR的关键因素。利用具有抗糖尿病和抗氧化活性的膳食黄酮的实验方法可能会保护糖尿病视网膜损伤。本研究旨在探讨柚皮素对链脲佐菌素诱导的糖尿病大鼠视网膜的潜在保护作用。糖尿病大鼠口服和未经治疗的柚皮素（50毫克/公斤/天）五周，视网膜的氧化应激，细胞凋亡和神经营养因子的标志物进行了分析。还分析了柚皮素治疗的全身效应，并与未治疗组进行比较。结果表明，糖尿病大鼠的硫代巴比妥酸反应物质（TBARS）水平升高和谷胱甘肽（GSH）水平下降，与柚皮素治疗得到改善。此外，糖尿病视网膜中神经保护因子（脑源性神经营养因子（BDNF））、原肌球蛋白相关激酶B（Trk B）和突触体素的水平降低随着柚皮素治疗而增强。此外，柚皮素治疗改善了糖尿病视网膜中凋亡调节蛋白的水平; B细胞淋巴瘤2（Bcl-2）、Bcl-2相关X蛋白（Bax）和半胱天冬酶-3。因此，该研究证明了具有抗糖尿病、抗氧化和抗凋亡特性的柚皮素的有益作用，其可以通过提供神经营养支持来限制神经变性，以防止糖尿病视网膜病变中的视网膜损伤。
Diabetic retinopathy (DR) is one of the leading causes of decreased vision and blindness worldwide. Diabetes-induced oxidative stress is believed to be the key factor that initiates neuronal damage in the diabetic retina leading to DR. Experimental approaches to utilize dietary flavonoids, which possess both antidiabetic and antioxidant activities, might protect the retinal damage in diabetes. The aim of this study was to investigate the potential protective effects of naringenin in the retina of streptozotocin-induced diabetic rats. Diabetic rats were orally treated and untreated with naringenin (50 mg/kg/day) for five weeks and retinas were analyzed for markers of oxidative stress, apoptosis and neurotrophic factors. Systemic effects of naringenin treatments were also analyzed and compared with untreated groups. The results showed that elevated levels of thiobarbituric acid reactive substances (TBARs) and decreased level of glutathione (GSH) in diabetic rats were ameliorated with naringenin treatments. Moreover, decreased levels of neuroprotective factors (Brain derived neurotrophic factor (BDNF)), tropomyosin related kinase B (TrkB) and synaptophysin in diabetic retina were augmented with naringenin treatments. In addition, naringenin treatment ameliorated the levels of apoptosis regulatory proteins; B cell lymphoma 2 (Bcl-2), Bcl-2 associated X protein (Bax) and caspase-3 in the diabetic retina. Thus, the study demonstrates the beneficial effects of naringenin that possesses anti-diabetic, antioxidant and antiapoptotic properties, which may limit neurodegeneration by providing neurotrophic support to prevent retinal damage in diabetic retinopathy.
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影响因子：
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