Dyssynchronous Pacing Triggers Endothelial-Mesenchymal Transition Through Heterogeneity of Mechanical Stretch in a Canine Model
Dyssynchronous Pacing Triggers Endothelial-Mesenchymal Transition Through Heterogeneity of Mechanical Stretch in a Canine Model
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犬模型中不同步起搏通过机械拉伸的异质性触发内皮间质转变
DOI：
10.1253/circj.cj-14-0721
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发表时间：
2015-01-01
影响因子：
3.3
通讯作者：
Wang, JingFeng
中科院分区：
文献类型：
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作者：
Mai, JingTing;Hu, QingSong;Wang, JingFeng
背景：内皮-间质转化（EndMT）在心脏纤维化中起关键作用。方法和结果：12只犬随机分为右心室快速起搏组（n=6）和双心室起搏组（n = 6），每组各6只。收缩功能BiVP组略优于RVP组（P
Background: Endothelial-mesenchymal transition (EndMT) plays a pivotal role in cardiac fibrosis. However, it is unclear whether EndMT is involved in dyssynchronous heart failure (DHF).Methods and Results: Twelve dogs received 3-week rapid right ventricular pacing (RVP) to develop DHF and then were randomly divided into a RVP group (n=6; RVP for another 3 weeks) and a biventricular pacing (BiVP) group (n=6; BiVP for 3 weeks), and another 6 dogs were in the control group. Contractile function in BiVP group was a little better than that in RVP group (P