Animal models of rheumatoid arthritis
Animal models of rheumatoid arthritis
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DOI：
10.1002/eji.200939578
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发表时间：
2009-08-01
影响因子：
5.4
通讯作者：
Liew, Foo Y.
中科院分区：
文献类型：
--
作者：
Asquith, Darren L.;Miller, Ashley M.;Liew, Foo Y.
动物模型已广泛应用于类风湿关节炎发病机制的研究。尽管所有动物模型都存在固有的局限性，但一些啮齿动物模型已经显著地促进了我们对类风湿关节炎基本机制的理解，并为当前治疗方面的一些重大进展做出了贡献。这些模型包括诱导性关节炎模型，如胶原诱导关节炎、胶原抗体诱导关节炎、酶生蛋白诱导关节炎和甲基化BSA模型，以及基因操纵或自发关节炎模型，如tnf - α转基因小鼠、K/BxN小鼠和Skg小鼠。在这里，我们描述了这些动物模型，并讨论了它们的优点和局限性。
Animal models have been used extensively in studies of rheumatoid arthritis pathogenesis. Despite the inherent limitations of all animal models, several rodent models have significantly progressed our understanding of the fundamental mechanisms underpinning rheumatoid arthritis and contributed to several current major advances in treatment. These models include the induced arthritis models such as collagen-induced arthritis, collagen-antibody-induced arthritis, zymosan-induced arthritis, and the methylated BSA model, and the genetically manipulated or spontaneous arthritis models such as the TNF-alpha-transgenic mouse, K/BxN mouse, and the Skg mouse. Here, we describe these animal models and discuss their advantages and limitations.