BSA-dextran emulsion for protection and oral delivery of curcumin
BSA-dextran emulsion for protection and oral delivery of curcumin
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用于姜黄素保护和口服递送的 BSA-葡聚糖乳剂
DOI：
10.1016/j.foodhyd.2016.04.037
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发表时间：
2016-12
影响因子：
10.7
通讯作者：
Ping Yao
中科院分区：
文献类型：
--
作者：
Zhijia Liu;Guangrui Xu;Baoru Yin;Ping Yao
In this study, BSA-dextran conjugate, produced by Maillard reaction, was used as emulsifier and stabilizer to produce curcumin-loaded oil in water emulsions. At fixed pH and BSA-dextran concentration in aqueous phase, the increases of curcumin concentration in oil phase from 12 to 15 mg/mL and oil volume fraction from 20% to 40% did not influence curcumin loading efficiency, but the oil-water interfacial films became imperfect, which were observed by transmission electron microscopy. The emulsion with integrated and cross-linked interfacial film formed on a heat treatment was long-term stable at various temperature and pH conditions, including physical stability of the emulsion and chemical stability of the loaded curcumin.Ex vivofluorescence images of mice by means of hydrophobic fluorescence probe-loaded BSA-dextran emulsion revealed that the emulsion and/or released probe were mainly in gastrointestinal tract after oral administration and almost disappeared at 24 h post-administration. The pharmacokinetics analysis demonstrated that curcumin-loaded BSA-dextran emulsion could increase curcumin oral bioavailability in mice by 4.8-fold compared with curcumin/Tween 20 suspension. This study verifies that the emulsion can protect loaded curcumin from decomposition and also can promote curcumin absorption in gastrointestinal tract, indicating that protein-polysaccharide emulsions are good oral delivery systems for hydrophobic drugs and nutrients.
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DOI：
10.3390/molecules20035165
发表时间：
2015-03-20
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Yin B;Zhang R;Yao P
通讯作者：
Yao P
影响因子：
8.1
作者：
Yuexi Yang;S. Cui;J. Gong;S. Miller;Qi Wang;Y. Hua
通讯作者：
Yuexi Yang;S. Cui;J. Gong;S. Miller;Qi Wang;Y. Hua
DOI：
10.1016/0166-6622(92)80109-f
发表时间：
1992-07-09
期刊：
COLLOIDS AND SURFACES
影响因子：
--
作者：
DICKINSON, E;SEMENOVA, MG
通讯作者：
SEMENOVA, MG
具有交联牛血清白蛋白界面膜和不同葡聚糖表面的热处理乳液：紫杉醇递送的影响
影响因子：
3.8
作者：
Qi, Jianing;Huang, Chong;Yao, Ping
通讯作者：
Yao, Ping
影响因子：
8.8
作者：
Xiaoyong Wang;Yan Jiang;Yuwen Wang;Mou-tuan Huang;Chi-Tang Ho;Qingrong Huang
通讯作者：
Xiaoyong Wang;Yan Jiang;Yuwen Wang;Mou-tuan Huang;Chi-Tang Ho;Qingrong Huang