Cerebrospinal Fluid and Interstitial Fluid Volume Measurements in the Human Brain at 3T with EPI
Cerebrospinal Fluid and Interstitial Fluid Volume Measurements in the Human Brain at 3T with EPI
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DOI：
10.1002/mrm.21915
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发表时间：
2009-04-01
影响因子：
3.3
通讯作者：
Klose, Uwe
中科院分区：
文献类型：
--
作者：
Bender, Benjamin;Klose, Uwe
脑脊液（CSIF）向脑室周围白色物质扩散是任何类型脑积水的病理生理特征之一。在标准的临床常规脑室周围高信号，脑室系统的大小，和侵入性脑脊液压力测量是关键的诊断方法。最近，He和Yablonskiy提出了一种称为定量血氧水平依赖（qBOLD）的方法（Magn Reson Med 2007;57：115-126），其使用GESSE序列的信号演变来提取关于血液动力学参数的定量信息。在这项研究中，一个类似的方法被用来提取体积分数的CSIF和间质液（ISF）在人脑中的信息。使用具有可变回波时间的标准梯度回波/回波平面成像（GRE-EPI）序列采集MRI信号。对健康受试者进行的第一次测试产生了一致的ISF/CSF体积分数结果，与文献中发现的结果非常一致。Magn Reson Med 61：834-841，2009。(C)2009 Wiley-Liss，Inc.
Cerebrospinal fluid (CSIF) diffusion into periventricular white matter is one of the pathophysiological features of hydrocephalus of any kind. In standard clinical routine periventricular hyperintensities, size of the ventricular system, and invasive CSF pressure measurement are the key diagnostic methods. Recently a method called quantitative blood oxygenation level-dependent (qBOLD) was proposed by He and Yablonskiy (Magn Reson Med 2007;57:115-126), which uses the signal evolution of a GESSE sequence to extract quantitative information about hemodynamic parameters. In this study a similar method was used to extract volume fraction information of CSIF and interstitial fluid (ISF) in the human brain. A standard gradient recalled echo/echo planar imaging (GRE-EPI) sequence with variable echo time was used for the acquisition of the MRI signal. A first test on healthy subjects yielded consistent results for ISF/CSF volume fraction, which were in good agreement with results found in the literature. Magn Reson Med 61:834-841, 2009. (C) 2009 Wiley-Liss, Inc.