Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.
Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma.
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DOI：
10.1097/qai.0b013e31828e6163
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发表时间：
2013-08-01
期刊：
影响因子：
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通讯作者：
Mellors JW
中科院分区：
文献类型：
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作者：
Cillo AR;Krishnan A;Mitsuyasu RT;McMahon DK;Li S;Rossi JJ;Zaia JA;Mellors JW
A cure of HIV-1 has been achieved in one individual through allogeneic stem cell transplantation with a CCR5delta32 homozygous donor. Whether myeloablation and autologous stem cell transplantation for lymphoma in patients on suppressive ART can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after autologous transplantation in 10 patients on suppressive ART using quantitative PCR assays capable of single copy nucleic acid detection. Plasma viremia was detectable in 9 patients and HIV-1 DNA was detectable in all 10 patients, indicating that HIV-1 had not been eliminated.
