Cannabis and cocaine use, drinking outcomes, and quality of life in general hospital inpatients with alcohol use disorder.
Cannabis and cocaine use, drinking outcomes, and quality of life in general hospital inpatients with alcohol use disorder.
复制标题
综合医院住院酒精使用障碍患者的大麻和可卡因使用、饮酒结果和生活质量。
DOI：
10.1080/08897077.2022.2074592
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发表时间：
2022
期刊：
影响因子：
3.5
通讯作者：
Saitz,Richard
中科院分区：
文献类型：
--
作者：
Romero-Rodríguez,Esperanza;Chen,ClaraA;Dukes,KimberlyA;Hartlage,Kaitlin;Palfai,TiborP;Magane,KaraM;Samet,JeffreyH;Saitz,Richard
背景资料：虽然大麻和可卡因的使用，以及大量饮酒和生活质量（QOL）之间的关联在一般人群中已经确立，但尚不清楚它们是否存在于酒精使用障碍（AUD）的住院患者中。该研究的目的是评估大麻和可卡因的使用和两个结果之间的关联[大量饮酒的日子（HDD）和生活质量]在医院住院患者与AUD。MethodsHospitalized患者与AUD和至少一个过去一个月的HDD参加了这项横断面研究。使用酒精、吸烟和物质参与筛选测试评估大麻和可卡因的使用情况。使用时间轴随访评估HDD。采用WHOQOL-BREF量表评定生活质量。多变量回归模型评估association.ResultsOf 248参与者，225（91%）有严重的AUD。近期大麻使用与HDD [发病率比（IRR）= 0.95; 95%置信区间（95% CI）：0.80，1.14]、可卡因使用与HDD [IRR = 0.88; 95% CI：0.66，1.18]或大麻和可卡因使用与HDD [IRR = 0.87; 95% CI：0.70，1.09]，与既不使用大麻也不使用可卡因相比。使用大麻、可卡因以及两者均与QOL无关[（比值比（OR）= 0.98; 95%CI：0.55，1.74），（OR = 0.76; 95%CI：0.30，1.93），（OR = 1.00; 95%CI：0.49，2.03），respectively]。我们的研究结果提出了关于药物使用如何影响AUD以及在轻度AUD患者和前瞻性研究中是否会发现类似结果的问题。
Background: While associations between cannabis and cocaine use, and heavy drinking and quality of life (QOL), are well-established in the general population, it is unclear whether they are present in hospital inpatients with alcohol use disorder (AUD). The aim of the study was to assess associations between cannabis and cocaine use and two outcomes [heavy drinking days (HDDs) and QOL] among hospital inpatients with AUD.MethodsHospitalized patients with AUD and at least one past-month HDD participated in this cross-sectional study. Cannabis and cocaine use were assessed using the Alcohol, Smoking, and Substance Involvement Screening Test. HDDs were assessed using the Timeline Followback. QOL was assessed by the WHOQOL–BREF instrument. Multivariable regression models assessed associations.ResultsOf 248 participants, 225 (91%) had severe AUD. There were no statistically significant associations between: recent cannabis use and HDDs [Incidence Rate Ratio (IRR) = 0.95; 95% Confidence Interval (95% CI): 0.80, 1.14], cocaine use and HDDs [IRR = 0.88; 95% CI: 0.66, 1.18], or both cannabis and cocaine use and HDDs [IRR = 0.87; 95%CI: 0.70, 1.09], as compared to use of neither cannabis nor cocaine. Use of cannabis, cocaine, and both, were not associated with QOL [(odds ratio (OR) = 0.98; 95% CI:0.55, 1.74), (OR = 0.76; 95% CI:0.30, 1.93), (OR = 1.00; 95%CI: 0.49, 2.03), respectively].ConclusionsAmong hospital inpatients with AUD, there were no significant associations between cannabis and cocaine use, heavy drinking, or QOL. Our findings raise questions regarding how drug use affects AUD and whether similar results would be found among those with milder AUD and in prospective studies.