REACTION OF THE TRICHLOROMETHYL AND HALOTHANE-DERIVED PEROXY-RADICALS WITH UNSATURATED FATTY-ACIDS - A PULSE-RADIOLYSIS STUDY
REACTION OF THE TRICHLOROMETHYL AND HALOTHANE-DERIVED PEROXY-RADICALS WITH UNSATURATED FATTY-ACIDS - A PULSE-RADIOLYSIS STUDY
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DOI：
10.1016/0009-2797(83)90066-2
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发表时间：
1983-01-01
影响因子：
5.1
通讯作者：
WILLSON, RL
中科院分区：
文献类型：
--
作者：
FORNI, LG;PACKER, JE;WILLSON, RL
自由基中间体参与了几种卤代有机化合物的肝毒性。用脉冲辐解快速反应技术测定了CCl4衍生的三氯甲基过氧基CCl3OO和氟烷过氧基CF3CHC1OO与油酸、亚油酸、亚麻酸和花生四烯酸的绝对反应速率。从CCl4衍生的自由基的反应速率为.apprx。比氟烷相关自由基大5倍。在这两种情况下，速率常数随着脂肪酸不饱和度的增加而增加，这与已知的多不饱和脂肪酸对过氧化分解的更大敏感性是一致的。
Free radical intermediates are involved in the hepatotoxicity of several halogenated organic compounds. The absolute rates of reaction of the trichloromethylperoxy radical, CCl3OO., derived from CCl4 and the halothane peroxy radical, CF3CHClOO., with oleic, linoleic, linolenic and arachidonic acids were determined using the fast reaction technique of pulse radiolysis. The rates of reaction of the radical derived from CCl4 were .apprx. 5-fold greater than those for the halothane related radical. In both cases the rate constant increased with increasing unsaturation of the fatty acid in agreement with the known greater susceptibility of polyunsaturated fatty acids to peroxidative decomposition.