Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen.
Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen.
复制标题
绝经后使用雌激素可降低髋部和下前臂骨折的风险。
DOI：
10.1056/nejm198011203032102
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
J. Daling
中科院分区：
文献类型：
--
作者：
N. Weiss;C. Ure;J. Ballard;A. Williams;J. Daling
我们采访了327名因前臂下部髋部骨折接受治疗时年龄在50至74岁之间的女性，以确定她们使用（或缺乏使用）雌激素制剂。他们的回答与来自同一地区的567名年龄相仿的妇女的随机样本进行了比较。使用这些药物6年或更长时间的女性骨折风险比未使用这些药物的女性低50%至60%（相对风险的95%置信区间为0.3至0.6）;使用这些药物时间较短的女性获得的益处较少，如果有的话。骨折风险的降低仅在仍服用雌激素的女性中明显，并且在每日普通剂量（0.625和1.25 mg）下明显。结合雌激素可以延缓绝经后妇女骨质疏松症的发展这一发现，我们的数据表明，降低髋部和前臂骨折的风险必须被视为长期使用雌激素的益处。
We interviewed 327 women who had been 50 to 74 years of age when treated for fracture of the hip of lower forearm, to determine their use (or lack of use) of estrogen preparations. Their responses were compared with those in a random sample of 567 women who were of similar age and from the same region. The risk of fracture was 50 to 60 per cent lower in women who had used these drugs for six years or longer than in women who hadnot used them (95 per cent confidence interval of relative risk, 0.3 to 0.6); those using them for shorter periods received less benefit, if any. A decreased risk of fracture was clearly evident only in women still taking estrogens and evident at either common daily dose (0.625 and 1.25 mg). In conjunction with the finding that estrogens can retard the development of osteoporosis in postmenopausal women, our data argue that lowering of the risk of hip and forearm fractures must be weighed as a benefit of long-term estrogen use.