The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression
The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression
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DOI：
10.1016/j.bmc.2015.09.049
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发表时间：
2015-11-01
影响因子：
3.5
通讯作者：
Nemoto, Hisao
中科院分区：
文献类型：
--
作者：
Shill, Manik Chandra;Das, Asish Kumar;Nemoto, Hisao
从孟加拉采集的一种植物红毛豆中分离得到一种新的具有苯并呋喃骨架的天然化合物。该化合物的化学合成证实了其结构，初步的生物学结果表明其对组胺H-1基因表达具有抑制活性。合成了1个异构体和4个衍生物，并考察了它们的抑制活性。虽然只有少量的化合物可以从其自然来源中分离出来，但新开发的方法证明了10g规模的合成。(C)2015爱思唯尔有限公司。保留所有权利。
A novel naturally occurring compound with a benzofuran skeleton was isolated from a plant, Tephrosia purpurea collected in Bangladesh. The chemical synthesis of this compound confirmed its structure, and preliminary biological results showed its suppressive activity towards histamine H-1 gene expression. One isomer and four derivatives were also synthesized, and their suppression activity was investigated. Although only small quantities of this compound can be isolated from its natural source, a 10 g scale synthesis was demonstrated by the newly developed method. (C) 2015 Elsevier Ltd. All rights reserved.