Overall time interval ("Total diagnostic delay") and mortality in symptomatic oral cancer: A U-shaped association
Overall time interval ("Total diagnostic delay") and mortality in symptomatic oral cancer: A U-shaped association
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DOI：
10.1016/j.oraloncology.2020.104626
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发表时间：
2020-05-01
期刊：
影响因子：
4.8
通讯作者：
Seoane-Romero, Juan
中科院分区：
文献类型：
--
作者：
Lopez-Cedrun, Jose L.;Varela-Centelles, Pablo;Seoane-Romero, Juan
目的：评价症状性口腔癌患者从首次体征变化(体征/症状)到治疗开始的总间隔时间对患者生存率的影响。方法：在《奥胡斯声明》的概念框架内设计以医院为基础的回顾性研究，以183例口腔癌患者的总体治疗间隔为例，分析其生存率。结果：总间隔时间(T5)：107.1+/-85.2d。总生存率：58.4(CI：51.3-66.4%)。复发时间(中位数)：724d(智商：223-2963.5)。中位生存期：1744d(智商：479.5-3438)。总的延迟时间(T5)与死亡率呈U型关系，短T5间期(24.0~55.5d)和长T5间期(127.5~420d)的病死率高于中T5间期(55.5~127.5天)。死亡率越高，时间间隔越短越长。当时间间隔被一分为二地考虑时，这可能会导致对关联的低估。
Objectives: To assess the impact on survival of the total time interval since the first bodily change (sign/symptom) until the start of treatment in symptomatic oral cancer patients.Methods: Retrospective, hospital-based study designed within the "Aarhus Statement" conceptual framework, using the overall interval to treatment of 183 oral cancer patients to analyse their survival rates.Results: Overall time interval (T5): 107.1 +/- 85.2 days. Overall survival rate: 58.4 (CI: 51.3-66.4%). Recurrence time (median): 724 days (IQR, 223-2963.5). Median survival time: 1744 days (IQR, 479.5-3438). Overall delay (T5) and mortality showed a U-shaped association, where patients with short (24.0-55.5 days) and long T5 intervals (127.5-420 days) had higher mortality than those with medium T5 intervals (55.5-127.5 days).Conclusion: There is a non-monotonic association between time interval and mortality. Higher mortality rates are linked to shorter and longer time intervals. This may induce underestimation of the association when time intervals are considered dichotomously.