Sumoylation in Cellular Senescence and Aging.
Sumoylation in Cellular Senescence and Aging.
复制标题
细胞衰老中的苏酰化。
DOI：
10.2174/1566524016666161
复制
发表时间：
2017
影响因子：
2.5
通讯作者：
Li D W-C
中科院分区：
文献类型：
--
作者：
Gong L;Sun Q;Li D W-C
SUMO化是一种可逆的翻译后修饰，将小肽SUMO（小泛素样修饰物）结合到靶蛋白上。近年来发现，在生物体衰老过程中，蛋白质类小泛素化和类小泛素化途径中各组分的表达发生了变化。此外，已知控制细胞衰老的关键因子被sumoylated。本文就类小泛素化在细胞衰老中的作用作一综述。
Sumoylation is a reversible post-translational modification that.conjugates small peptide SUMO (small ubiquitin-like modifier) to a target.protein. Global protein sumoylation and expression of components in.sumoylation pathway were recently found to be altered in the process of.organismal aging. In addition, key factors controlling cellular senescence are.known to be sumoylated. This review will summarize current information on.the function of sumoylation in cellular senescence and aging.