Diagnostic and therapeutic applications of angiogenesis research.
Diagnostic and therapeutic applications of angiogenesis research.
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血管生成研究的诊断和治疗应用。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
J. Folkman
中科院分区：
文献类型：
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作者：
J. Folkman
过去30年来在实验室中阐明的血管生成过程的某些原理现在已经转化为临床应用。这些应用在预后、抑制血管生成和加速血管生成的领域。随着从这些研究中获得更多的经验，我们可能开始看到许多其他血管生成疾病的治疗方法的发展，包括糖尿病视网膜病变、类风湿性关节炎和银屑病。它有可能增加心肌梗死的新生血管形成率，甚至可能刺激冠状动脉侧支血管的生长。从这些实验室和临床研究中，已经清楚的是，血管生成是在医学和外科的许多不同分支中主导疾病的基本过程。清楚地了解这一过程的生物学和分子学方面对于成功治疗广泛的“血管生成性疾病”至关重要[53]。
Certain principles of the angiogenic process elucidated in the laboratory over the past 3 decades have now been translated to clinical application. These applications are in the areas of prognosis, inhibition of angiogenesis, and acceleration of angiogenesis. As more experience is gained from these studies we may begin to see the development of therapies for many other angiogenic diseases, including diabetic retinopathy, rheumatoid arthritis, and psoriasis. It may be possible to increase the rate of neovascularization of a myocardial infarction and perhaps even to stimulate the growth of coronary collateral vessels. From these laboratory and clinical studies it has become clear that angiogenesis is a fundamental process that dominates diseases in many different branches of medicine and surgery. A clear understanding of the biological and molecular aspects of this process will be critical to the successful treatment of a wide spectrum of "angiogenic diseases" [53].