Measures of Abdominal Adiposity and the Risk of Stroke The MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Study
Measures of Abdominal Adiposity and the Risk of Stroke The MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Study
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DOI：
10.1161/strokeaha.111.614099
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发表时间：
2011-10-01
期刊：
影响因子：
8.3
通讯作者：
Dallongeville, Jean
中科院分区：
文献类型：
--
作者：
Bodenant, Marie;Kuulasmaa, Kari;Dallongeville, Jean
背景和目的——多余的脂肪积聚在皮下和内脏脂肪组织室中。我们测试了以下假设：内脏肥胖指标，即腰围 (WC)、腰臀比 (WHR) 和腰臀比 (WHtR) 比体重指数 (BMI) 更能预测中风风险。方法 - 在 31 201 名男性和 23 516 名无血管疾病的女性中评估了 BMI、WC、WHR 和 WHtR 与中风的关联。 基线疾病，来自 MONica 风险、遗传学、存档和专着 (MORGAM) 研究。在平均 11 年的随访期间，记录了 1130 例中风。中心分层并调整年龄、吸烟、教育水平、饮酒、高血压、糖尿病、总胆固醇、高密度脂蛋白胆固醇和 BMI 后，通过 Cox 回归计算相对风险 (95% CI)，并使用对数似然评估模型拟合度。结果 - BMI、WC、WHR 和 WHtR 与男性中风风险相关。在包括 BMI 在内的全面调整后，WC（WC 每增加 1 个 SD，1.19 [1.02 至 1.34]）、WHR（1.14 [1.03 至 1.26]）和 WHtR（1.50 [1.28 至 1.77]）的中风相对风险仍然显着。在女性中，WHtR（1.31 [1.04 - 1.65]）、WC（1.19 [0.96 - 1.47]）和WHR（1.08 [0.97 - 1.22]）与卒中风险的关联程度相似。世界卫生组织肥胖类别的进一步分析表明，腰围、腰臀比和腰臀比在瘦男性和女性中也与中风风险相关（BMI
Background and Purpose-Excess fat accumulates in the subcutaneous and visceral adipose tissue compartments. We tested the hypothesis that indicators of visceral adiposity, namely, waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR), are better predictors of stroke risk than body mass index (BMI).Methods-The association of BMI, WC, WHR, and WHtR with stroke was assessed in 31 201 men and 23 516 women, free of vascular disease at baseline, from the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) study. During a mean follow-up of 11 years, 1130 strokes were recorded. Relative risks (95% CI) were calculated by Cox regression after stratification for center and adjustment for age, smoking, educational level, alcohol consumption, hypertension, diabetes, total cholesterol, high-density lipoprotein cholesterol, and BMI and model fit was assessed using log-likelihoods.Results-BMI, WC, WHR, and WHtR were associated with the risk of stroke in men. After full adjustment including BMI, the relative risks for stroke remained significant for WC (1.19 [1.02 to 1.34] per 1 SD increase in WC), WHR (1.14 [1.03 to 1.26]), and WHtR (1.50 [1.28 to 1.77]). Among women, the extent of the associations with stroke risk was similar for WHtR (1.31 [1.04 to 1.65]), WC (1.19 [0.96 to 1.47]), and WHR (1.08 [0.97 to 1.22]). Further analyses by World Health Organization obesity categories showed that WC, WHR, and WHtR were associated with the risk of stroke also in lean men and women (BMI