ADAPTIVE EVOLUTION IN THE STOMACH LYSOZYMES OF FOREGUT FERMENTERS
ADAPTIVE EVOLUTION IN THE STOMACH LYSOZYMES OF FOREGUT FERMENTERS
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DOI：
10.1038/330401a0
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发表时间：
1987-11-26
期刊：
影响因子：
64.8
通讯作者：
WILSON, AC
中科院分区：
文献类型：
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作者：
STEWART, CB;SCHILLING, JW;WILSON, AC
两组哺乳动物发酵前肠的趋同进化为研究蛋白质水平的适应性进化提供了机会。这种消化模式的出现伴随着溶菌酶在反刍动物（例如牛）和后来的疣猴（例如叶猴）胃中作为溶菌酶的补充。这两类胃溶菌酶具有一些共同的理化和催化特性，这些特性似乎使它们能够在胃液中发挥作用1,2。为了检查这些共同特性的基础，我们对叶猴胃溶菌酶进行了测序，并将其与已知序列的其他溶菌酶进行了比较。树分析表明，在猴子的前肠发酵发生后，叶猴溶菌酶获得了与牛胃溶菌酶的序列相似性，并且进化速度比其他灵长类溶菌酶快两倍。这种快速进化，加上牛胃溶菌酶的功能和序列趋同，可能意味着正达尔文选择驱动了叶猴胃溶菌酶约 50% 的进化。
The convergent evolution of a fermentative foregut in two groups of mammals offers an opportunity to study adaptive evolution at the protein level. The appearance of this mode of digestion has been accompanied by the recruitment of lysozyme as a bacteriolytic enzyme in the stomach both in the ruminants (for example the cow) and later in the colobine monkeys (for example the langur). The stomach lysozymes of these two groups share some physicochemical and catalytic properties that appear to adapt them for functioning in the stomach fluid1,2. To examine the basis for these shared properties, we sequenced langur stomach lysozyme and compared it to other lysozymes of known sequence. Tree analysis suggests that, after foregut fermentation arose in monkeys, the langur lysozyme gained sequence similarity to cow stomach lysozyme and evolved two times faster than the other primate lysozymes. This rapid evolution, coupled with functional and sequence convergence upon cow stomach lysozyme, could imply that positive darwinian selection has driven about 50% of the evolution of langur stomach lysozyme.