Binge eating: neurochemical insights from animal models.
Binge eating: neurochemical insights from animal models.
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DOI：
10.1080/10640260802371604
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发表时间：
2009-01-01
期刊：
影响因子：
3.3
通讯作者：
Avena, Nicole M
中科院分区：
文献类型：
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作者：
Avena, Nicole M
从暴饮暴食的动物模型中产生的数据已经产生了关于生理和神经化学变化的重要见解，这些变化可能是异常饮食行为的原因或后果。为了研究暴饮暴食行为，已经开发了几种动物模型（参见Corwin & Buda-Levin， 2004）。一些模型鼓励饱腹动物自愿暴饮暴食，提供有限的机会（例如，每天2小时）获得美味的食物，如那些高脂肪或高糖的食物（Berner, Avena, & Hoebel, 2008; Dimitriou, Rice, & Corwin, 2000），除了自由地获得标准的啮齿动物食物。其他模型包括适度食物剥夺的时期，以刺激动物在美味食物出现时暴食（Avena, Rada, & Hoebel, 2008b）。通过胃瘘假喂养，其中食物的摄入量不受胃容量的限制，也被用于模拟暴饮暴食，允许大鼠在短时间内摄入大量流质食物（Avena, Rada, Moise, & Hoebel, 2006; Smith, 1989）。压力源也会促使大鼠暴饮暴食（Boggiano et al., 2005）。
A. Data generated from animal models of binge eating have yielded important insights pertaining to physiological and neurochemical alterations that may be the cause, or consequence, of abnormal eating behaviors. Several animal models have been developed for the study of binge-eating behavior (see Corwin & Buda-Levin, 2004 for review). Some models encourage voluntary binge eating in sated animals by offering limited access (eg, 2-h/day) to a palatable food, such as those high in fat or sugar (Berner, Avena, & Hoebel, 2008; Dimitriou, Rice, & Corwin, 2000), in addition to ad libitum access to standard rodent chow. Other models incorporate periods of moderate food deprivation in order to stimulate animals to binge eat when a palatable food is presented (Avena, Rada, & Hoebel, 2008b). Sham feeding via a gastric fistula, in which the amount of food consumed is not constrained by stomach capacity, has also been used to model binge eating by allowing rats to consume large amounts of liquid food in a brief period of time (Avena, Rada, Moise, & Hoebel, 2006; Smith, 1989). Stressors can also precipitate binge eating in rats (Boggiano et al., 2005).