Impedance matched channel walls in acoustofluidic systems
Impedance matched channel walls in acoustofluidic systems
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DOI：
10.1039/c3lc51109j
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发表时间：
2014-01-01
期刊：
影响因子：
6.1
通讯作者：
Dual, Jurg
中科院分区：
文献类型：
--
作者：
Leibacher, Ivo;Schatzer, Sebastian;Dual, Jurg
体声波（BAW）装置中的声泳通常在两个相对的硅壁之间的微流体通道中利用超声驻波操作，所述硅壁充当声学和流体边界两者。在本文中，我们描述了BAW器件与聚二甲基硅氧烷（PDMS）的附加材料层。该PDMS壁被引入以通过声阻抗匹配将声学边界（硅壁）与流体边界（PDMS壁）解耦。因此，与传统BAW设备相比，声场和由此产生的颗粒操纵受到的限制较少。在所提出的装置中，颗粒积聚线可以任意放置在流体域内，这大大增加了声电泳的可能性。本文包括实验结果，良好的协议和PDMS封装在微通道的微加工技术的分析模型。最后给出了微粒浓缩的应用实例。所提出的方法提供了进一步的潜在的生物技术应用，如颗粒分离，增强颗粒传感器和细胞处理。
Acoustophoresis in bulk acoustic wave (BAW) devices typically operates with an ultrasonic standing wave in a microfluidic channel between two opposing silicon walls, which act as both the acoustic and the fluidic boundary. In this paper, we describe BAW devices with an additional material layer of polydimethylsiloxane (PDMS). This PDMS wall is introduced to decouple the acoustic boundary (silicon wall) from the fluidic boundary (PDMS wall) by acoustic impedance matching. The acoustic field and the resulting particle manipulation are thereby less restricted than in conventional BAW devices. In the presented devices, particle accumulation lines can be placed arbitrarily within the fluidic domain, which strongly increases the possibility of acoustophoresis. The paper covers experimental results, an analytical model in good agreement and microfabrication techniques for PDMS enclosed in a microchannel. An application example for microparticle concentration is demonstrated. The presented approach offers further potential for biotechnological applications such as particle separation, enhanced particle sensors and cell handling.