Varying Correlation Between 18F-Fluorodeoxyglucose Positron Emission Tomography and Dynamic Contrast-Enhanced MRI in Carotid Atherosclerosis Implications for Plaque Inflammation
Varying Correlation Between 18F-Fluorodeoxyglucose Positron Emission Tomography and Dynamic Contrast-Enhanced MRI in Carotid Atherosclerosis Implications for Plaque Inflammation
复制标题
F-18-氟脱氧葡萄糖正电子发射断层扫描和动态增强 MRI 之间不同的相关性对颈动脉粥样硬化斑块炎症的影响
DOI：
10.1161/strokeaha.114.005147
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发表时间：
2014-06-01
期刊：
影响因子：
8.3
通讯作者：
Chen, Huijun
中科院分区：
文献类型：
--
作者：
Wang, Juan;Liu, Hongbin;Chen, Huijun
背景和目的-F-18-氟脱氧葡萄糖正电子发射断层扫描和动态对比增强MRI已被提议分别通过探测巨噬细胞和新生血管来定量评估斑块炎症。我们检测了它们之间的相关性，以研究动脉粥样硬化形成中巨噬细胞和新生血管活性之间的体内关系。（34名男性;年龄65 ± 12岁），共68处颈动脉斑块（超声显示厚度>= 2 mm; 20例有症状）通过F-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描和动态对比剂进行评估，结果总体而言，靶背景比与K-transs之间的相关性较弱且边缘（r=0.22; P=0.068）。在有症状的斑块中两者相关（r=0.59; P=0.006），但在无症状斑块中不相关（r=0.07; P=0.625; P=0.033）。在有症状的斑块中，目标与背景比值和K-transs均不显著升高，但均与自上次神经事件以来的时间呈反比关系（r=-0.94和-0.69为目标-背景比和K-transs，分别）.结论-F-18-氟脱氧葡萄糖正电子发射断层扫描和动态对比增强MRI测量之间的相关性随临床条件而变化，表明在不同病理生理条件下巨噬细胞和新生血管之间存在复杂的相互作用。仅在症状性斑块中显示的中度相关性表明存在急性斑块炎症，伴有炎症细胞代谢活性和细胞因子产生增加。
Background and Purpose-F-18-fluorodeoxyglucose positron emission tomography and dynamic contrast-enhanced MRI have been proposed to quantitatively assess plaque inflammation by probing macrophages and neovessels, respectively. We examined their correlation to study the in vivo relationship between macrophage and neovessel activities in atherogenesis.Methods-Forty-one patients (34 men; aged 65 +/- 12 years) with a total of 68 carotid plaques (thickness >= 2 mm on ultrasound; 20 symptomatic) were assessed by both F-18-fluorodeoxyglucose positron emission tomography/computed tomography and dynamic contrast-enhanced MRI within 2 weeks, measured as target-to-background ratio and transfer constant (K-trans), respectively.Results-Overall, the correlation between target-to-background ratio and K-trans was weak and marginal (r=0.22; P=0.068). They were correlated in the symptomatic plaques (r=0.59; P=0.006) but not in the asymptomatic plaques (r=0.07; P=0.625; P=0.033 for difference in r). Neither target-to-background ratio nor K-trans was significantly higher in the symptomatic plaques, but both showed an inverse relationship with time since last neurological event (r=-0.94 and -0.69 for target-to-background ratio and K-trans, respectively).Conclusions-The correlation between F-18-fluorodeoxyglucose positron emission tomography and dynamic contrast-enhanced MRI measurements varied with clinical conditions, pointing to a complex interplay between macrophages and neovessels under different pathophysiological conditions. The moderate correlation shown only in symptomatic plaques indicates the presence of acute plaque inflammation with increased metabolic activity and cytokine production by inflammatory cells.