THERMOTROPIC STRUCTURAL CHANGE OF DISIALOGANGLIOSIDE MICELLES STUDIED BY USING SYNCHROTRON RADIATION SMALL-ANGLE X-RAY SCATTERING
THERMOTROPIC STRUCTURAL CHANGE OF DISIALOGANGLIOSIDE MICELLES STUDIED BY USING SYNCHROTRON RADIATION SMALL-ANGLE X-RAY SCATTERING
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同步辐射小角X射线散射研究双唾液酸神经节苷脂胶束的热致结构变化
DOI：
10.1021/jp960235q
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Kouhei Hayashi
中科院分区：
文献类型：
--
作者：
M. Hirai;T. Takizawa;S. Yabuki;and Toshihiro Hirai;Kouhei Hayashi
本文采用同步辐射x射线散射的方法研究了双胞苷（GD1）胶束的热致性结构变化。散射数据和分析表明，在20℃左右，热致性结构变化伴随着胶束整体尺寸的收缩和胶束内部结构的变化。双壳模型分析合理地描述了观测到的实验散射曲线、距离分布函数和结构参数的变化。模拟分析表明，温度升高引起胶束结构的主要变化是亲水性区域的收缩和平均散射密度的增加，表明低聚糖链的构象由延伸型变为折叠型。同时，随着平均散射密度的轻微增加，疏水区发生了轻微的延伸，表明烃链发生了轻微的重排。W……
This work treats the thermotropic structural change of the disialoganglioside (GD1) micelles studied by using synchrotron radiation X-ray scattering. Scattering data and analyses show that thermotropic structural change around 20 °C accompanies the contraction of the whole micellar dimension and the internal structural change of the micelles. Double-shell modeling analyses reasonably describe the observed changes in the experimental scattering curves, distance distribution functions, and structural parameters. The modeling analyses show that the major changes of the micellar structure induced by the elevation of temperature are the contraction of the hydrophilic region and the increase of the average scattering density, suggesting the change of the oligosaccharide chain conformation from an extended one to a folded one. Simultaneously, the minor extension of the hydrophobic region occurs with a slight increase of the average scattering density, suggesting a minor rearrangement of the hydrocarbon chains. W...