Using fast visual rhythmic stimulation to control inter-hemispheric phase offsets in visual areas.
Using fast visual rhythmic stimulation to control inter-hemispheric phase offsets in visual areas.
复制标题
使用快速视觉节律刺激来控制视觉区域的半球间相位偏移。
DOI：
10.1016/j.neuropsychologia.2021.107863
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发表时间：
2021
期刊：
影响因子：
2.6
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Chen Q
Spike timing dependent plasticity （STDP）被认为对人类情景记忆的神经交流和可塑性具有重要意义，但由于技术上的挑战，缺乏因果证据。有节奏的感官刺激已被用于研究振荡和认知之间的因果关系，可能能够解决这个问题。然而，挑战在于STDP的临界时间窗对应的频率是伽马（~40 Hz），而节律性感官刺激的应用主要局限于较低的频率（<30 Hz）。目前尚不清楚这种方法是否可以应用于精确控制相距遥远的神经元组之间毫秒级的激活时间延迟。为了回答这个问题并研究STDP在人类情景记忆中的作用，我们通过控制记忆编码过程中左右视觉皮层之间的激活时间延迟来模拟STDP功能。这是通过在左右视野中呈现闪烁（37.5 Hz）电影对，相位滞后为0,90,180或270°来实现的。参与者被要求记住每组中的两部电影，然后对这种联系进行测试。行为学结果显示，在不同的伽马相位同步程度条件下，记忆表现没有显著差异。然而重要的是，我们的研究首次表明，振荡活动可以在神经元组之间以6.67 ms的延迟精度驱动。因此，我们的方法提供了一种研究精确神经元计时和认知功能之间关系的方法。
Spike timing dependent plasticity (STDP) is believed to be important for neural communication and plasticity in human episodic memory, but causal evidence is lacking due to technical challenges. Rhythmic sensory stimulation that has been used to investigate causal relations between oscillations and cognition may be able to address this question. The challenge, however, is that the frequency corresponding to the critical time window for STDP is gamma (~40 Hz), yet the application of rhythmic sensory stimulation has been limited primarily to lower frequencies (<30 Hz). It remains unknown whether this method can be applied to precisely control the activation time delay between distant groups of neurons at a millisecond scale. To answer this question and examine the role of STDP in human episodic memory, we simulated the STDP function by controlling the activation time delay between the left and right visual cortices during memory encoding. This was achieved by presenting flickering (37.5 Hz) movie pairs in the left and right visual fields with a phase lag of either 0, 90, 180 or 270°. Participants were asked to memorize the two movies within each pair and the association was later tested. Behavioral results revealed no significant difference in memory performance across conditions with different degrees of gamma phase synchrony. Yet importantly, our study showed for the first time, that oscillatory activity can be driven with a precision of 6.67 ms delay between neuronal groups. Our method hereby provides an approach to investigate relations between precise neuronal timing and cognitive functions.