Biological mechanisms and therapeutic relevance of the gasdermin family.
Biological mechanisms and therapeutic relevance of the gasdermin family.
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DOI：
10.1016/j.mam.2020.100890
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发表时间：
2020-12
影响因子：
10.6
通讯作者：
Xia S
中科院分区：
文献类型：
--
作者：
Xia S
天然免疫通过炎性小体使宿主能够防御病原体和内源性危险，炎性小体是识别威胁并激活免疫反应的超分子复合体。炎性小体激活通常会导致下垂，这是一种高度炎症和溶解的细胞死亡形式，作为一种杀死感染细胞和释放与其他细胞沟通的IL-1家族细胞因子的手段。炎症小体信号的失调会导致一系列的免疫疾病，包括痛风、败血症和肝炎。Gasdermin D(GSDMD)是一种致孔蛋白，是一个具有多种细胞功能和病理作用的新家族，是一种在下垂中被发现的直接杀伤分子。现就GSDM家族，尤其是GSDMD的生物学机制和治疗价值的研究进展作一综述。介绍了GSDM家族的自我抑制和孔形成的详细机制，然后简要总结了GSDM靶向治疗的发展进展。
Innate immunity enables host defense against pathogens and endogenous danger through inflammasomes, which are supramolecular complexes that recognize the threats and activate the immune response. Inflammasome activation often leads to pyroptosis, a highly inflammatory and lytic form of cell death, as a means of killing infected cells and releasing IL-1 family cytokines that communicate with other cells. Dysregulated inflammasome signaling results in a wide range of immune disorders including gout, sepsis, and hepatitis. Discovered as a direct killer molecule in pyroptosis, gasdermin D (GSDMD) is a pore-forming protein that represents a novel family with diverse cellular functions and pathological roles. This review summarizes current opinions in the biological mechanisms and therapeutic values of the GSDM family, particularly of GSDMD. Detailed mechanisms of auto-inhibition and pore formation by the GSDM family are presented, followed by a brief summary of the progress in the development of GSDM-targeting therapeutics.
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形成孔的蛋白质加油D可以调节白细胞介素-1的巨噬细胞分泌。
影响因子：
32.4
作者：
Evavold CL;Ruan J;Tan Y;Xia S;Wu H;Kagan JC
通讯作者：
Kagan JC
DOI：
10.1073/pnas.1607769113
发表时间：
2016-07-12
影响因子：
11.1
作者：
Aglietti, Robin A.;Estevez, Alberto;Dueber, Erin C.
通讯作者：
Dueber, Erin C.
影响因子：
64.8
作者：
Ding, Jingjin;Wang, Kun;Shao, Feng
通讯作者：
Shao, Feng
影响因子：
11
作者：
Lin PH;Lin HY;Kuo CC;Yang LT
通讯作者：
Yang LT
NLRC4诱导自我繁殖的结构和生化基础
影响因子：
56.9
作者：
Hu, Zehan;Zhou, Qiang;Chai, Jijie
通讯作者：
Chai, Jijie