ACCELERATION OF DIABETES IN YOUNG NOD MICE WITH A CD4+ ISLET-SPECIFIC T-CELL CLONE
ACCELERATION OF DIABETES IN YOUNG NOD MICE WITH A CD4+ ISLET-SPECIFIC T-CELL CLONE
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DOI：
10.1126/science.2205920
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发表时间：
1990-09-21
期刊：
影响因子：
56.9
通讯作者：
MCDUFFIE, M
中科院分区：
文献类型：
--
作者：
HASKINS, K;MCDUFFIE, M
非肥胖型糖尿病（NOD）小鼠在3个月大后发展为自身免疫性糖尿病，变得高血糖。通过向年轻NOD小鼠注射来自NOD小鼠的CD4+胰岛特异性T细胞克隆，这一过程得以加速。在19只实验动物中，有10只在7周龄时出现了明显的糖尿病，其余的老鼠则显示出疾病进展的明显迹象。对照组小鼠没有患糖尿病，也没有明显的胰腺浸润。这项工作表明，CD4 T细胞克隆足以启动糖尿病易发NOD小鼠的疾病过程。
Nonobese diabetic (NOD) mice develop an autoimmune form of diabetes, becoming hyperglycemic after 3 months of age. This process was accelerated by injecting young NOD mice with CD4+islet-specific T cell clones derived from NOD mice. Overt diabetes developed in 10 of 19 experimental animals by 7 weeks of age, with the remaining mice showing marked signs of the disease in progress. Control mice did not become diabetic and had no significant pancreatic infiltration. This work demonstrates that a CD4 T cell clone is sufficient to initiate the disease process in the diabetes-prone NOD mouse.