Human coronavirus OC43 causes influenza-like illness in residents and staff of aged-care facilities in Melbourne, Australia
Human coronavirus OC43 causes influenza-like illness in residents and staff of aged-care facilities in Melbourne, Australia
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DOI：
10.1017/s0950268804003346
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发表时间：
2005-04-01
影响因子：
4.2
通讯作者：
Druce, JD
中科院分区：
文献类型：
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作者：
Birch, CJ;Clothier, HJ;Druce, JD
2002年8月和9月期间，在澳大利亚墨尔本地理位置无关的老年护理机构发生了三起与人类冠状病毒HCoV-OC 43感染相关的呼吸道疾病暴发。从临床和流行病学的角度来看，这些暴发最初被认为是由流感病毒引起的。通过RT-PCR在27份标本中的16份（59%）中检测到HCoV-OC 43，并且是采样时检测到的唯一病毒。常见临床表现为咳嗽（74%）、口炎（59%）、咽痛（53%）.所有设施的居民和工作人员的发病率和症状相似。HCoV-OC 43也在同一个月的监测和诊断呼吸道样本中检测到。这些爆发确立了这种病毒是老年护理机构发病的原因，并增加了冠状病毒感染重要性的证据。
Three outbreaks of respiratory illness associated with human coronavirus HCoV-OC43 infection occurred in geographically unrelated aged-care facilities in Melbourne, Australia during August and September 2002. On clinical and epidemiological grounds the outbreaks were first thought to be caused by influenza virus. HCoV-OC43 was detected by RT-PCR in 16 out of 27 (59%) specimens and was the only virus detected at the time of sampling. Common clinical manifestations were cough (74 %), rhinorrhoca (59 %) and sore throat (53 %). Attack rates and symptoms were similar in residents and staff across the facilities. HCoV-OC43 was also detected in surveillance and diagnostic respiratory samples in the same months. These outbreaks establish this virus as a cause of morbidity in aged-care facilities and add to increasing evidence of the significance of coronavirus infections.