EFFECT OF COMBINED MATERNAL AND INFANT FOOD-ALLERGEN AVOIDANCE ON DEVELOPMENT OF ATOPY IN EARLY INFANCY - A RANDOMIZED STUDY
EFFECT OF COMBINED MATERNAL AND INFANT FOOD-ALLERGEN AVOIDANCE ON DEVELOPMENT OF ATOPY IN EARLY INFANCY - A RANDOMIZED STUDY
复制标题
DOI：
10.1016/0091-6749(89)90181-4
复制
发表时间：
1989-07-01
影响因子：
14.2
通讯作者：
SCHATZ, M
中科院分区：
文献类型：
--
作者：
ZEIGER, RS;HELLER, S;SCHATZ, M
在一项对特应性父母的婴儿进行的产前随机对照试验中，研究了母亲和婴儿避免过敏性食物对食物过敏的影响。酪蛋白处理组（N = 103）的饮食包括（1）母亲在妊娠晚期和哺乳期避免牛奶、鸡蛋和花生，（2）婴儿使用酪蛋白水解物（Nutramigen）用于补充或断奶，并避免固体食物6个月;牛奶，玉米，大豆，柑橘和小麦，12个月;鸡蛋花生和鱼，24个月在对照组（N = 185）中，母亲的饮食不受限制，婴儿遵循美国儿科学会的喂养指南。在12个月时，特应性的累积患病率较低，（16.2%）与对照组相比（27.1%）组（p = 0.039），原因是12个月时食物相关的特应性皮炎、荨麻疹和/或胃肠道疾病减少（5.1%对16.4%; p = 0.007），以及24个月时任何食物皮肤试验阳性（16.5%对29.4%; p = 0.019），主要是由于较少的阳性牛奶皮肤试验（1%对12.4%; p = 0.001）。过敏性鼻炎、哮喘和吸入性皮肤试验的患病率未受影响。仅在4个月时，抗过敏药物治疗组的血清IgE水平略低。因此，减少婴儿接触致敏性食物似乎主要在生命的第一年减少食物致敏和过敏。
The effect of maternal and infant avoidance of allergenic foods on food allergy was examined in a prenatally randomized, controlled trial of infants of atopic parents. The diet of the prophylactic-treated group (N = 103) included (1) maternal avoidance of cow''s milk, egg, and peanut during the third trimester of pregnancy and lactation and (2) infant use of casein hydrolysate (Nutramigen) for supplementation or weaning, and avoidance of solid foods for 6 months; cow''s milk, corn, soy, citrus, and wheat, for 12 months; and egg, peanut, and fish, for 24 months. In the control group (N = 185), mothers had unrestricted diets, and infants followed American Academy of Pediatrics feeding guidelines. The cumulative prevalence of atopy was lower at 12 months in the prophylactic-treated (16.2%) compared to the control (27.1%) group (p = 0.039), resulting from reduced food-associated atopic dermatitis, urticaria and/or gastrointestinal disease by 12 months (5.1% versus 16.4%; p = 0.007), and any positive food skin test by 24 months (16.5% versus 29.4%; p = 0.019), caused primarily by fewer positive milk skin tests (1% versus 12.4%; p = 0.001). The prevalence of allergic rhinitis, asthma, and inhalant skin tests were unaffected. Serum IgE levels in the prophylactic-treated group were marginally lower only at 4 months. Thus, reduced exposure of infants to allergenic foods appeared to reduce food sensitization and allergy primarily during the first year of life.