Amacrine-to-amacrine cell inhibition in the rabbit retina
Amacrine-to-amacrine cell inhibition in the rabbit retina
复制标题
DOI：
10.1152/jn.90417.2008
复制
发表时间：
2008-10-01
影响因子：
2.5
通讯作者：
Werblin, Frank S.
中科院分区：
文献类型：
--
作者：
Hsueh, Hain-Ann;Molnar, Alyosha;Werblin, Frank S.
我们在膜片钳下研究了光适应兔视网膜切片上形态鉴定的无长突细胞的兴奋和抑制之间的相互作用。大多数无长突细胞受到甘氨酸能OFF抑制。约有一半的无长突细胞受到甘氨酸能抑制。两个班级都没有受到任何GABA能抑制。少数ON、OFF和ON-OFF无长突细胞同时受到甘氨酸能ON和GABA能OFF抑制。这些相互作用在不同形态的细胞中被发现，这些细胞具有宽的和窄的突起，这些突起在内丛状层(IPL)的单层或多层中分层。大多数开关的无长突细胞没有受到抑制，其单层突起局限在IPL的中间。我们测量到的无长突细胞之间最常见的相互作用是“交叉抑制”，即关抑制开，开抑制关。尽管无长突细胞的形态多种多样，但刺激和抑制之间的相互作用似乎相对有限和特异。
We studied the interactions between excitation and inhibition in morphologically identified amacrine cells in the light-adapted rabbit retinal slice under patch clamp. The majority of ON amacrine cells received glycinergic OFF inhibition. About half of the OFF amacrine cells received glycinergic ON inhibition. Neither class received any GABAergic inhibition. A minority of ON, OFF, and ON-OFF amacrine cells received both glycinergic ON and GABAergic OFF inhibition. These interactions were found in cells with diverse morphologies having both wide and narrow processes that stratify in single or multiple layers of the inner plexiform layer (IPL). Most ON-OFF amacrine cells received no inhibition and have monostratified processes confined to the middle of the IPL. The most common interaction between amacrine cells that we measured was "crossover inhibition," where OFF inhibits ON and ON inhibits OFF. Although the morphology of amacrine cells is diverse, the interactions between excitation and inhibition appear to be relatively limited and specific.